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Gene Set: D4 : CTD - GDC-0973

Collection D4 : CTD
Chemical Name GDC-0973 ( From PubChem : COBIMETINIB )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
NotNotNotNotNotNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
531.31 g/mol 3 4 4.1208 False(3/4)
Structure
InChI InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChIKey BSMCAPRUBJMWDF-KRWDZBQOSA-N
Links

Gene (9 / 17)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDaffects(cotreatment)BCL2L11
C574276
CTDdecreases(phosphorylation)BCL2L11
C574276
CTDincreases(expression)BCL2L11
C574276
CTDincreases(reaction)BCL2L11
C574276
CTDincreases(reaction)BRAF
C574276
CTDincreases(response to substance)BRAF
C574276
CTDdecreases(expression)CCND1
C574276
CTDincreases(reaction)CCND1
C574276
CTDincreases(reaction)KRAS
C574276
CTDincreases(response to substance)KRAS
C574276
CTDdecreases(phosphorylation)MAPK1
C574276
CTDdecreases(phosphorylation)MAPK3
C574276
CTDincreases(response to substance)NRAS
C574276
CTDincreases(cleavage)PARP1
C574276
CTDincreases(reaction)PARP1
C574276
CTDdecreases(phosphorylation)RPS6
C574276
CTDincreases(reaction)RPS6
C574276
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