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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate

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Collection	D4 : CTD
Chemical Name	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate ( From PubChem : CHLORPYRIFOS OXON )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 334.521 g/mol 0 5 4.6017 True
Structure
InChI	InChI=1S/C9H11Cl3NO4P/c1-3-15-18(14,16-4-2)17-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
InChIKey	OTMOUPHCTWPNSL-UHFFFAOYSA-N
Links
Gene (107 / 225) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) ABCB1 C009618 CTD affects(binding) ACHE C009618 CTD decreases(activity) ACHE C009618 CTD decreases(activity) ACHE C009618 CTD increases(phosphorylation) ACHE C009618 CTD affects(binding) ACHE C009618 CTD decreases(reaction) ACHE C009618 CTD affects(expression) ACTG1 C009618 CTD affects(response to substance) ACTG1 C009618 CTD decreases(response to substance) ALB C009618 CTD decreases(activity) ALB C009618 CTD increases(hydrolysis) ALB C009618 CTD affects(binding) ALB C009618 CTD affects(expression) ALDH18A1 C009618 CTD affects(response to substance) ALDH18A1 C009618 CTD affects(expression) ANK3 C009618 CTD affects(response to substance) ANK3 C009618 CTD decreases(activity) APEH C009618 CTD affects(expression) APOC1 C009618 CTD affects(response to substance) APOC1 C009618 CTD affects(expression) ATP2B2 C009618 CTD affects(response to substance) ATP2B2 C009618 CTD affects(expression) ATP5H C009618 CTD affects(response to substance) ATP5H C009618 CTD affects(expression) ATP5J2 C009618 CTD affects(response to substance) ATP5J2 C009618 CTD affects(expression) ATP5L C009618 CTD affects(response to substance) ATP5L C009618 CTD decreases(activity) BCHE C009618 CTD decreases(response to substance) BCHE C009618 CTD decreases(activity) BCHE C009618 CTD affects(expression) BPNT1 C009618 CTD affects(response to substance) BPNT1 C009618 CTD affects(expression) CACNA1F C009618 CTD affects(response to substance) CACNA1F C009618 CTD decreases(activity) CES1 C009618 CTD affects(expression) CHERP C009618 CTD affects(response to substance) CHERP C009618 CTD affects(expression) CNTFR C009618 CTD affects(response to substance) CNTFR C009618 CTD affects(expression) COX15 C009618 CTD affects(response to substance) COX15 C009618 CTD affects(expression) COX6C C009618 CTD affects(response to substance) COX6C C009618 CTD affects(expression) COX7A2 C009618 CTD affects(response to substance) COX7A2 C009618 CTD affects(expression) COX7A2L C009618 CTD affects(response to substance) COX7A2L C009618 CTD affects(expression) CPT1C C009618 CTD affects(response to substance) CPT1C C009618 CTD affects(expression) CYB5A C009618 CTD affects(response to substance) CYB5A C009618 CTD affects(chemical synthesis) CYP2B6 C009618 CTD increases(chemical synthesis) CYP2B6 C009618 CTD increases(chemical synthesis) CYP2B6 C009618 CTD increases(chemical synthesis) CYP3A4 C009618 CTD affects(expression) DCTN1 C009618 CTD affects(response to substance) DCTN1 C009618 CTD affects(expression) DHODH C009618 CTD affects(response to substance) DHODH C009618 CTD affects(expression) DLG4 C009618 CTD affects(response to substance) DLG4 C009618 CTD affects(expression) DPYSL2 C009618 CTD affects(response to substance) DPYSL2 C009618 CTD affects(expression) ELAVL3 C009618 CTD affects(response to substance) ELAVL3 C009618 CTD affects(expression) EPHB1 C009618 CTD affects(response to substance) EPHB1 C009618 CTD affects(expression) ERC2 C009618 CTD affects(response to substance) ERC2 C009618 CTD decreases(activity) ESR1 C009618 CTD affects(expression) FIS1 C009618 CTD affects(response to substance) FIS1 C009618 CTD affects(expression) HK1 C009618 CTD affects(response to substance) HK1 C009618 CTD affects(expression) HK2 C009618 CTD affects(response to substance) HK2 C009618 CTD affects(expression) INA C009618 CTD affects(response to substance) INA C009618 CTD affects(expression) LETM1 C009618 CTD affects(response to substance) LETM1 C009618 CTD affects(expression) MGST1 C009618 CTD affects(response to substance) MGST1 C009618 CTD affects(expression) MYLIP C009618 CTD affects(response to substance) MYLIP C009618 CTD affects(expression) NCAM1 C009618 CTD affects(response to substance) NCAM1 C009618 CTD affects(expression) NDUFA1 C009618 CTD affects(response to substance) NDUFA1 C009618 CTD affects(expression) NDUFA12 C009618 CTD affects(response to substance) NDUFA12 C009618 CTD affects(expression) NDUFA13 C009618 CTD affects(response to substance) NDUFA13 C009618 CTD affects(expression) NDUFA2 C009618 CTD affects(response to substance) NDUFA2 C009618 CTD affects(expression) NDUFA4 C009618 CTD affects(response to substance) NDUFA4 C009618 CTD affects(expression) NDUFA5 C009618 CTD affects(response to substance) NDUFA5 C009618 CTD affects(expression) NDUFA6 C009618 CTD affects(response to substance) NDUFA6 C009618 CTD affects(expression) NDUFB11 C009618 CTD affects(response to substance) NDUFB11 C009618 CTD affects(expression) NDUFB3 C009618 CTD affects(response to substance) NDUFB3 C009618 CTD affects(expression) NDUFB4 C009618 CTD affects(response to substance) NDUFB4 C009618 CTD affects(expression) NDUFB5 C009618 CTD affects(response to substance) NDUFB5 C009618 CTD affects(expression) NDUFB6 C009618 CTD affects(response to substance) NDUFB6 C009618 CTD affects(expression) NDUFB8 C009618 CTD affects(response to substance) NDUFB8 C009618 CTD affects(expression) NDUFS6 C009618 CTD affects(response to substance) NDUFS6 C009618 CTD affects(expression) NDUFV2 C009618 CTD affects(response to substance) NDUFV2 C009618 CTD affects(expression) NF1 C009618 CTD affects(response to substance) NF1 C009618 CTD affects(expression) NLGN1 C009618 CTD affects(response to substance) NLGN1 C009618 CTD affects(expression) NLGN2 C009618 CTD affects(response to substance) NLGN2 C009618 CTD affects(expression) NLGN3 C009618 CTD affects(response to substance) NLGN3 C009618 CTD affects(expression) NOG C009618 CTD affects(response to substance) NOG C009618 CTD affects(expression) NOS1AP C009618 CTD affects(response to substance) NOS1AP C009618 CTD affects(expression) NRXN2 C009618 CTD affects(response to substance) NRXN2 C009618 CTD affects(expression) NSF C009618 CTD affects(response to substance) NSF C009618 CTD affects(expression) OXA1L C009618 CTD affects(response to substance) OXA1L C009618 CTD affects(expression) PAM16 C009618 CTD affects(response to substance) PAM16 C009618 CTD affects(expression) PMPCA C009618 CTD affects(response to substance) PMPCA C009618 CTD decreases(activity) PNPLA6 C009618 CTD affects(response to substance) PNPLA6 C009618 CTD decreases(response to substance) PNPLA6 C009618 CTD affects(binding) PON1 C009618 CTD increases(hydrolysis) PON1 C009618 CTD affects(expression) PON1 C009618 CTD affects(response to substance) PON1 C009618 CTD affects(metabolic processing) PON1 C009618 CTD decreases(response to substance) PON1 C009618 CTD increases(response to substance) PON1 C009618 CTD decreases(response to substance) PON1 C009618 CTD increases(hydrolysis) PON1 C009618 CTD affects(expression) PON2 C009618 CTD affects(response to substance) PON2 C009618 CTD affects(expression) PPFIA3 C009618 CTD affects(response to substance) PPFIA3 C009618 CTD affects(expression) RIMS4 C009618 CTD affects(response to substance) RIMS4 C009618 CTD affects(expression) SDCBP2 C009618 CTD affects(response to substance) SDCBP2 C009618 CTD affects(expression) SEMA4B C009618 CTD affects(response to substance) SEMA4B C009618 CTD affects(expression) SEMA4F C009618 CTD affects(response to substance) SEMA4F C009618 CTD affects(expression) SEMA5B C009618 CTD affects(response to substance) SEMA5B C009618 CTD affects(expression) SLC25A14 C009618 CTD affects(response to substance) SLC25A14 C009618 CTD affects(expression) SLC25A16 C009618 CTD affects(response to substance) SLC25A16 C009618 CTD affects(expression) SLC25A37 C009618 CTD affects(response to substance) SLC25A37 C009618 CTD affects(expression) SLC25A44 C009618 CTD affects(response to substance) SLC25A44 C009618 CTD affects(expression) SLC7A5 C009618 CTD affects(response to substance) SLC7A5 C009618 CTD affects(expression) SLIT3 C009618 CTD affects(response to substance) SLIT3 C009618 CTD affects(expression) SNAPIN C009618 CTD affects(response to substance) SNAPIN C009618 CTD affects(expression) SPTB C009618 CTD affects(response to substance) SPTB C009618 CTD affects(expression) STAT3 C009618 CTD affects(response to substance) STAT3 C009618 CTD affects(expression) SUCLG1 C009618 CTD affects(response to substance) SUCLG1 C009618 CTD affects(expression) SYN1 C009618 CTD affects(response to substance) SYN1 C009618 CTD affects(expression) SYN2 C009618 CTD affects(response to substance) SYN2 C009618 CTD affects(expression) SYN3 C009618 CTD affects(response to substance) SYN3 C009618 CTD affects(expression) SYT1 C009618 CTD affects(response to substance) SYT1 C009618 CTD affects(binding) TF C009618 CTD affects(expression) TIMM10 C009618 CTD affects(response to substance) TIMM10 C009618 CTD affects(expression) TIMM17A C009618 CTD affects(response to substance) TIMM17A C009618 CTD affects(expression) TIMM8B C009618 CTD affects(response to substance) TIMM8B C009618 CTD affects(expression) TNR C009618 CTD affects(response to substance) TNR C009618 CTD affects(expression) TOMM22 C009618 CTD affects(response to substance) TOMM22 C009618 CTD affects(expression) UNC13A C009618 CTD affects(response to substance) UNC13A C009618 CTD affects(expression) UQCRC2 C009618 CTD affects(response to substance) UQCRC2 C009618 CTD affects(expression) VPS13A C009618 CTD affects(response to substance) VPS13A C009618 PubChem Ratio Potency (uM) uM 46.840 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 27.140 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem Potency-Replicate_1 uM 12.226 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 43.385 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 44.696 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 48.262 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.741 NR1H4 - GI(Protien) : PubChem None uM NR1H4 - GI(Protien) : PubChem Potency-Replicate_1 uM 27.371 NR3C1 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 12.226 PPARD - GI(Protien) : PubChem None uM PPARD - GI(Protien) : PubChem Potency-Replicate_1 uM 1.372 PPARG - GI(Protien) : PubChem None uM VDR - GI(Protien) :
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