Tan Lab | DSigDB

Gene Set: D4 : CTD - aristolochic acid I

Collection

D4 : CTD

Chemical Name

aristolochic acid I ( From PubChem : ARISTOLOCHIC ACID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
341.272 g/mol	1	5	3.8599	True

Structure

InChI

InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

InChIKey

BBFQZRXNYIEMAW-UHFFFAOYSA-N

Links

Gene (26 / 65)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ACTA2		C000228
CTD	increases(expression)			ACTA2		C000228
CTD	decreases(activity)			BMP7		C000228
CTD	decreases(expression)			BMP7		C000228
CTD	decreases(response to substance)			BMP7		C000228
CTD	decreases(reaction)			BMP7		C000228
CTD	decreases(reaction)			CASP3		C000228
CTD	increases(activity)			CASP3		C000228
CTD	decreases(expression)			CDH1		C000228
CTD	decreases(reaction)			CDH1		C000228
CTD	increases(oxidation)			CYP1A1		C000228
CTD	increases(chemical synthesis)			CYP1A1		C000228
CTD	increases(activity)			CYP1A1		C000228
CTD	increases(reduction)			CYP1A1		C000228
CTD	increases(chemical synthesis)			CYP1A2		C000228
CTD	increases(oxidation)			CYP1A2		C000228
CTD	increases(activity)			CYP1A2		C000228
CTD	increases(reduction)			CYP1A2		C000228
CTD	increases(expression)			DDIT3		C000228
CTD	increases(phosphorylation)			EIF2S1		C000228
CTD	increases(expression)			EPAS1		C000228
CTD	increases(expression)			GREM1		C000228
CTD	decreases(activity)			GREM1		C000228
CTD	decreases(reaction)			GREM1		C000228
CTD	decreases(expression)			GREM1		C000228
CTD	decreases(response to substance)			GREM1		C000228
CTD	increases(expression)			HSPA5		C000228
CTD	increases(phosphorylation)			MAPK1		C000228
CTD	increases(phosphorylation)			MAPK3		C000228
CTD	decreases(reaction)			SLC22A11		C000228
CTD	increases(uptake)			SLC22A11		C000228
CTD	increases(export)			SLC22A11		C000228
CTD	increases(reaction)			SLC22A11		C000228
CTD	decreases(reaction)			SLC22A6		C000228
CTD	increases(uptake)			SLC22A6		C000228
CTD	increases(export)			SLC22A6		C000228
CTD	increases(reaction)			SLC22A6		C000228
CTD	decreases(reaction)			SLC22A8		C000228
CTD	increases(uptake)			SLC22A8		C000228
CTD	increases(export)			SLC22A8		C000228
CTD	increases(reaction)			SLC22A8		C000228
CTD	decreases(expression)			SMAD1		C000228
CTD	decreases(reaction)			SMAD1		C000228
CTD	decreases(expression)			SMAD5		C000228
CTD	decreases(reaction)			SMAD5		C000228
CTD	decreases(expression)			SMAD9		C000228
CTD	decreases(reaction)			SMAD9		C000228
CTD	increases(expression)			VEGFA		C000228
CTD	decreases(reaction)			VEGFA		C000228
CTD	increases(splicing)			XBP1		C000228
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPT	-	GI(Protien) :
PubChem	Potency	uM	14.125	MAPT	-	GI(Protien) :
PubChem	Potency	uM	17.783	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.582	NFE2L2	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	8.177	TDP1	-	GI(Protien) :
PubChem	Potency	uM	11.550	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	Potency	uM	29.855	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	12589.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	17782.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	11582.100	NFE2L2	-	Target : CHEMBL1075094

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