Tan Lab | DSigDB

Gene Set: D4 : CTD - tolfenamic acid

Collection

D4 : CTD

Chemical Name

tolfenamic acid ( From PubChem : TOLFENAMIC ACID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
261.704 g/mol	2	2	4.1632	True

Structure

InChI

InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

InChIKey

YEZNLOUZAIOMLT-UHFFFAOYSA-N

Links

Gene (21 / 46)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AKR1C3		C009500
CTD	decreases(response to substance)			AKR1C3		C009500
CTD	increases(reaction)			AKR1C3		C009500
CTD	decreases(activity)			AKR1C3		C009500
CTD	decreases(activity)			AKR1C3		C009500
CTD	increases(chemical synthesis)			AKR1C3		C009500
CTD	increases(metabolic processing)			AKR1C3		C009500
CTD	decreases(activity)			ALB		C009500
CTD	decreases(reaction)			ALB		C009500
CTD	decreases(activity)			CYP1A2		C009500
CTD	decreases(reaction)			CYP1A2		C009500
CTD	decreases(activity)			CYP1A2		C009500
CTD	decreases(reaction)			KLK3		C009500
CTD	increases(expression)			KLK3		C009500
CTD	increases(secretion)			KLK3		C009500
CTD	increases(expression)			PSMB10		C009500
CTD	increases(expression)			PSMB9		C009500
PubChem	IC50_Mean	uM	8.170	ATG4B	-	GI(Protien) :
PubChem	None	uM		ATG4B	-	GI(Protien) :
PubChem	None	uM		ATG4B	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	44.668	EHMT2	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	14.125	HPGD	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	23.708	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.601	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	IC50_Mean	uM	7.740	PLA2G1B	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	IC50	nM	8170.000	ATG4B	-	Target : CHEMBL1741221
ChEMBL	AC50	nM	3162.280	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	3162.280	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	3162.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	44668.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	14125.400	HPGD	-	Target : CHEMBL1293255

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