Tan Lab | DSigDB

Gene Set: D4 : CTD - HhAntag691

Collection

D4 : CTD

Chemical Name

HhAntag691 ( From PubChem : VISMODEGIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
421.297 g/mol	1	5	5.865	False(3/4)

Structure

InChI

InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)

InChIKey

Links

Gene (14 / 32)

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Source	Type	Unit	Gene	PMID	Other
CTD	affects(cotreatment)		BCL2		C538724
CTD	affects(reaction)		BCL2		C538724
CTD	decreases(expression)		BCL2		C538724
CTD	increases(cleavage)		CASP3		C538724
CTD	increases(expression)		CDH1		C538724
CTD	affects(cotreatment)		FAS		C538724
CTD	affects(reaction)		FAS		C538724
CTD	increases(expression)		FAS		C538724
CTD	affects(cotreatment)		GLI1		C538724
CTD	affects(reaction)		GLI1		C538724
CTD	decreases(expression)		GLI1		C538724
CTD	increases(expression)		GLI1		C538724
CTD	affects(response to substance)		GLI1		C538724
CTD	affects(cotreatment)		GLI2		C538724
CTD	affects(reaction)		GLI2		C538724
CTD	decreases(expression)		GLI2		C538724
CTD	increases(expression)		GLI2		C538724
CTD	affects(response to substance)		GLI2		C538724
CTD	affects(cotreatment)		PDGFRA		C538724
CTD	affects(reaction)		PDGFRA		C538724
CTD	decreases(expression)		PDGFRA		C538724
CTD	decreases(expression)		PTCH1		C538724
CTD	decreases(expression)		PTCH2		C538724
CTD	decreases(expression)		SMO		C538724
CTD	affects(cotreatment)		TNFRSF10A		C538724
CTD	affects(reaction)		TNFRSF10A		C538724
CTD	increases(expression)		TNFRSF10A		C538724
CTD	affects(cotreatment)		TNFRSF10B		C538724
CTD	affects(reaction)		TNFRSF10B		C538724
CTD	increases(expression)		TNFRSF10B		C538724
CTD	decreases(expression)		ZEB1		C538724
ChEMBL	Inhibition	-	SHH	-	Target : CHEMBL5602

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