Tan Lab | DSigDB

Gene Set: D4 : CTD - tetrandrine

Collection

D4 : CTD

Chemical Name

tetrandrine ( From PubChem : TETRANDRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
622.75 g/mol	0	8	7.0382	False(2/4)

Structure

InChI

InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

InChIKey

WVTKBKWTSCPRNU-KYJUHHDHSA-N

Links

Gene (19 / 34)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ABCB1		C009438
CTD	affects(response to substance)			BCL2		C009438
CTD	decreases(expression)			BCL2		C009438
CTD	affects(binding)			BIRC5		C009438
CTD	decreases(expression)			BIRC5		C009438
CTD	increases(expression)			CDKN1A		C009438
CTD	increases(glutathionylation)			CYP3A4		C009438
CTD	increases(glutathionylation)			CYP3A5		C009438
PubChem	Potency	uM	25.119	ATXN2	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	Potency	uM	5.805	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		PREPL	-	GI(Protien) :
PubChem	None	uM		PREPL	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	2.237	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.593	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.464	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.012	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.414	TDP1	-	GI(Protien) :
PubChem	Potency	uM	11.220	TDP1	-	GI(Protien) :
PubChem	Potency	uM	31.623	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	50118.700	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	31622.800	TP53	-	Target : CHEMBL4096

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