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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide

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Collection	D4 : CTD
Chemical Name	2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide ( From PubChem : VELIPARIB )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 244.292 g/mol 3 4 2.2895 True
Structure
InChI	InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
InChIKey	JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Links
Gene (20 / 42) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(transport) ABCB1 C521013 CTD increases(activity) ATM C521013 CTD increases(phosphorylation) ATM C521013 CTD affects(cotreatment) BAK1 C521013 CTD increases(response to substance) BAK1 C521013 CTD affects(cotreatment) BAX C521013 CTD increases(response to substance) BAX C521013 CTD affects(cotreatment) BCL2L1 C521013 CTD decreases(response to substance) BCL2L1 C521013 CTD affects(response to substance) BRCA1 C521013 CTD decreases(response to substance) BRCA1 C521013 CTD affects(response to substance) BRCA2 C521013 CTD increases(metabolic processing) CYP1A2 C521013 CTD increases(metabolic processing) CYP2C19 C521013 CTD increases(metabolic processing) CYP2D6 C521013 CTD increases(metabolic processing) CYP3A4 C521013 CTD affects(localization) EGFR C521013 CTD decreases(response to substance) EGFR C521013 CTD increases(expression) ERCC1 C521013 CTD increases(reaction) ERCC1 C521013 CTD increases(expression) ERCC4 C521013 CTD increases(reaction) ERCC4 C521013 CTD affects(cotreatment) H2AFX C521013 CTD increases(expression) H2AFX C521013 CTD increases(expression) H2AFX C521013 CTD increases(reaction) H2AFX C521013 CTD increases(expression) H2AFX C521013 CTD increases(expression) H2AFX C521013 CTD decreases(reaction) H2AFX C521013 CTD increases(reaction) MPG C521013 CTD increases(response to substance) MPG C521013 CTD decreases(response to substance) MRE11A C521013 CTD decreases(activity) PARP1 C521013 CTD increases(expression) PARP1 C521013 CTD increases(expression) PARP1 C521013 CTD affects(cotreatment) PARP1 C521013 CTD affects(response to substance) PARP1 C521013 CTD decreases(activity) PARP2 C521013 CTD affects(binding) PARP2 C521013 CTD decreases(reaction) TDP1 C521013 CTD increases(expression) TDP1 C521013 CTD increases(reaction) TDP1 C521013
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