Tan Lab | DSigDB

Gene Set: D4 : CTD - SCIO-469

Collection

D4 : CTD

Chemical Name

SCIO-469 ( From PubChem : TALMAPIMOD )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
513.003 g/mol	0	7	3.8525	False(3/4)

Structure

InChI

InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1

InChIKey

ZMELOYOKMZBMRB-DLBZAZTESA-N

Links

Gene (13 / 29)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	decreases(expression)		BCL2L1		C499748
CTD	increases(reaction)		BCL2L1		C499748
CTD	increases(cleavage)		CASP3		C499748
CTD	increases(reaction)		CASP3		C499748
CTD	increases(cleavage)		CASP6		C499748
CTD	increases(reaction)		CASP6		C499748
CTD	increases(cleavage)		CASP7		C499748
CTD	increases(reaction)		CASP7		C499748
CTD	increases(cleavage)		CASP8		C499748
CTD	increases(reaction)		CASP8		C499748
CTD	increases(cleavage)		CASP9		C499748
CTD	increases(reaction)		CASP9		C499748
CTD	decreases(phosphorylation)		MAPK14		C499748
CTD	increases(activity)		MAPK8		C499748
CTD	increases(phosphorylation)		MAPK8		C499748
CTD	increases(reaction)		MAPK8		C499748
CTD	increases(activity)		MAPK9		C499748
CTD	increases(phosphorylation)		MAPK9		C499748
CTD	increases(reaction)		MAPK9		C499748
CTD	decreases(activity)		MAPKAPK2		C499748
CTD	affects(cotreatment)		MCL1		C499748
CTD	decreases(expression)		MCL1		C499748
CTD	increases(cleavage)		MCL1		C499748
CTD	increases(reaction)		MCL1		C499748
CTD	increases(cleavage)		PARP1		C499748
CTD	increases(reaction)		PARP1		C499748
CTD	increases(expression)		TP53		C499748
CTD	increases(reaction)		TP53		C499748
ChEMBL	Activity	-	MAPK14	-	Target : CHEMBL260

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