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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide

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Collection	D4 : CTD
Chemical Name	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide ( From PubChem : NILOTINIB )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Not Approved Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 529.516 g/mol 2 7 6.5018 False(2/4)
Structure
InChI	InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
InChIKey	HHZIURLSWUIHRB-UHFFFAOYSA-N
Links
Gene (18 / 50) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(abundance) ABCC10 C498826 CTD decreases(reaction) ABCC10 C498826 CTD increases(secretion) ABCC10 C498826 CTD decreases(response to substance) ABCC10 C498826 CTD affects(cotreatment) ABL1 C498826 CTD decreases(phosphorylation) ABL1 C498826 CTD decreases(reaction) ABL1 C498826 CTD increases(phosphorylation) ABL1 C498826 CTD affects(binding) ABL1 C498826 CTD decreases(reaction) ABL1 C498826 CTD increases(chemical synthesis) ABL1 C498826 CTD increases(expression) ABL1 C498826 CTD decreases(phosphorylation) ABL1 C498826 CTD increases(phosphorylation) ACACA C498826 CTD decreases(expression) ATF6 C498826 CTD increases(reaction) ATF6 C498826 CTD affects(binding) BCR C498826 CTD decreases(reaction) BCR C498826 CTD increases(chemical synthesis) BCR C498826 CTD increases(expression) BCR C498826 CTD decreases(phosphorylation) BCR C498826 CTD increases(activity) CASP3 C498826 CTD increases(cleavage) CASP3 C498826 CTD increases(activity) CASP7 C498826 CTD increases(cleavage) CASP7 C498826 CTD affects(cotreatment) CRKL C498826 CTD decreases(phosphorylation) CRKL C498826 CTD decreases(reaction) CRKL C498826 CTD increases(phosphorylation) CRKL C498826 CTD increases(expression) DDIT3 C498826 CTD increases(reaction) DDIT3 C498826 CTD increases(expression) EDEM1 C498826 CTD increases(reaction) EDEM1 C498826 CTD increases(expression) FOS C498826 CTD increases(reaction) FOS C498826 CTD increases(expression) GCLM C498826 CTD increases(reaction) GCLM C498826 CTD affects(binding) HDC C498826 CTD decreases(reaction) HDC C498826 CTD increases(expression) HDC C498826 CTD decreases(expression) HDC C498826 CTD increases(expression) HSPA5 C498826 CTD increases(reaction) HSPA5 C498826 CTD increases(expression) JUN C498826 CTD increases(phosphorylation) JUN C498826 CTD increases(reaction) JUN C498826 CTD increases(expression) JUNB C498826 CTD increases(reaction) JUNB C498826 CTD decreases(activity) KCNH2 C498826 CTD increases(expression) XBP1 C498826
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