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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one

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Collection	D4 : CTD
Chemical Name	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one ( From PubChem : KU-55933 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 395.495 g/mol 0 6 4.8242 True
Structure
InChI	InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChIKey	XRKYMMUGXMWDAO-UHFFFAOYSA-N
Links
Gene (19 / 86) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ATM C495818 CTD increases(phosphorylation) ATM C495818 CTD increases(reaction) ATM C495818 CTD decreases(reaction) ATM C495818 CTD increases(activity) ATM C495818 CTD decreases(activity) ATM C495818 CTD decreases(reaction) ATM C495818 CTD increases(phosphorylation) ATM C495818 CTD decreases(reaction) ATM C495818 CTD increases(activity) ATM C495818 CTD decreases(reaction) ATM C495818 CTD increases(phosphorylation) ATM C495818 CTD decreases(activity) ATM C495818 CTD increases(cleavage) CASP7 C495818 CTD increases(reaction) CASP7 C495818 CTD decreases(expression) CCND1 C495818 CTD decreases(phosphorylation) CCND1 C495818 CTD decreases(reaction) CDKN1A C495818 CTD increases(expression) CDKN1A C495818 CTD decreases(reaction) CDKN1A C495818 CTD increases(expression) CDKN1A C495818 CTD decreases(reaction) CHEK1 C495818 CTD increases(phosphorylation) CHEK1 C495818 CTD decreases(reaction) CHEK2 C495818 CTD increases(phosphorylation) CHEK2 C495818 CTD decreases(reaction) CHEK2 C495818 CTD increases(phosphorylation) CHEK2 C495818 CTD decreases(reaction) CHEK2 C495818 CTD increases(phosphorylation) CHEK2 C495818 CTD increases(reaction) CHEK2 C495818 CTD decreases(reaction) CHEK2 C495818 CTD increases(activity) CHEK2 C495818 CTD decreases(phosphorylation) CHEK2 C495818 CTD affects(binding) EIF4E C495818 CTD increases(reaction) EIF4E C495818 CTD affects(binding) EIF4EBP1 C495818 CTD increases(reaction) EIF4EBP1 C495818 CTD decreases(phosphorylation) EIF4EBP1 C495818 CTD decreases(expression) EIF4EBP1 C495818 CTD decreases(expression) FAS C495818 CTD decreases(reaction) GSK3B C495818 CTD increases(phosphorylation) GSK3B C495818 CTD decreases(reaction) H2AFX C495818 CTD increases(activity) H2AFX C495818 CTD increases(phosphorylation) H2AFX C495818 CTD increases(reaction) H2AFX C495818 CTD decreases(phosphorylation) H2AFX C495818 CTD increases(reaction) H2AFX C495818 CTD decreases(reaction) IGF1 C495818 CTD increases(activity) IGF1 C495818 CTD increases(phosphorylation) IGF1 C495818 CTD decreases(reaction) INS C495818 CTD increases(phosphorylation) INS C495818 CTD increases(activity) PARP1 C495818 CTD increases(cleavage) PARP1 C495818 CTD increases(reaction) PARP1 C495818 CTD decreases(phosphorylation) PRKDC C495818 CTD increases(reaction) PRKDC C495818 CTD decreases(reaction) SMC1A C495818 CTD increases(phosphorylation) SMC1A C495818 CTD increases(reaction) SMC1A C495818 CTD decreases(reaction) SQSTM1 C495818 CTD increases(degradation) SQSTM1 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD increases(reaction) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(activity) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(expression) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(expression) TP53 C495818 CTD decreases(reaction) TP53 C495818 CTD increases(expression) TP53 C495818 CTD increases(phosphorylation) TP53 C495818 CTD decreases(phosphorylation) TP53 C495818 CTD decreases(reaction) TRIM28 C495818 CTD increases(phosphorylation) TRIM28 C495818 CTD increases(reaction) TRIM28 C495818 ChEMBL Inhibition - ATM - Target : CHEMBL3797
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