Tan Lab | DSigDB

Gene Set: D4 : CTD - N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide

Collection

D4 : CTD

Chemical Name

N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide ( From PubChem : IMD-0354 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
383.673 g/mol	2	3	5.4085	False(3/4)

Structure

InChI

InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChIKey

Links

Gene (13 / 30)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			CXCL8		C492919
CTD	increases(expression)			CXCL8		C492919
CTD	decreases(reaction)			CXCL8		C492919
CTD	increases(secretion)			CXCL8		C492919
CTD	decreases(expression)			F11R		C492919
CTD	decreases(reaction)			F11R		C492919
CTD	decreases(reaction)			GCLC		C492919
CTD	increases(expression)			GCLC		C492919
CTD	decreases(reaction)			HMOX1		C492919
CTD	increases(expression)			HMOX1		C492919
CTD	decreases(reaction)			IER3		C492919
CTD	increases(expression)			IER3		C492919
CTD	decreases(activity)			IKBKB		C492919
CTD	decreases(response to substance)			IKBKB		C492919
CTD	decreases(reaction)			MMP9		C492919
CTD	increases(expression)			MMP9		C492919
CTD	decreases(reaction)			NFKBIA		C492919
CTD	increases(phosphorylation)			NFKBIA		C492919
CTD	decreases(reaction)			SRXN1		C492919
CTD	increases(expression)			SRXN1		C492919
CTD	decreases(reaction)			TNF		C492919
CTD	increases(secretion)			TNF		C492919
CTD	decreases(reaction)			TNF		C492919
CTD	increases(expression)			TNF		C492919
CTD	decreases(reaction)			ZFAND2A		C492919
CTD	increases(expression)			ZFAND2A		C492919
PubChem	Potency	uM	0.354	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.397	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.706	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	29.935	POLK	-	GI(Protien) :

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