Tan Lab | DSigDB

Gene Set: D4 : CTD - 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole

Collection

D4 : CTD

Chemical Name

2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole ( From PubChem : DMAT )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
476.788 g/mol	1	2	4.6789	True

Structure

InChI

InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)

InChIKey

Links

Gene (13 / 30)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AKT1		C492322
CTD	increases(phosphorylation)			AKT1		C492322
CTD	affects(binding)			CSNK2A1		C492322
CTD	affects(cotreatment)			CSNK2A1		C492322
CTD	decreases(reaction)			CSNK2A1		C492322
CTD	increases(reaction)			CSNK2A1		C492322
CTD	decreases(activity)			IKZF1		C492322
CTD	decreases(reaction)			IKZF1		C492322
CTD	decreases(reaction)			MAPK1		C492322
CTD	increases(phosphorylation)			MAPK1		C492322
CTD	decreases(reaction)			MAPK3		C492322
CTD	increases(phosphorylation)			MAPK3		C492322
CTD	affects(binding)			SLC39A7		C492322
CTD	affects(cotreatment)			SLC39A7		C492322
CTD	decreases(reaction)			SLC39A7		C492322
CTD	increases(reaction)			SLC39A7		C492322
CTD	increases(phosphorylation)			SLC39A7		C492322
PubChem	Potency	uM	1.458	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	16.360	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.501	NFKB1	-	GI(Protien) :
PubChem	Potency	uM	1.259	THPO	-	GI(Protien) :
ChEMBL	Potency	nM	1457.500	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Activity	-		CSNK2A1	-	Target : CHEMBL2095191
ChEMBL	Activity	-		CSNK2A2	-	Target : CHEMBL2095191
ChEMBL	Activity	-		CSNK2B	-	Target : CHEMBL2095191
ChEMBL	Potency	nM	19952.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	16360.100	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	501.200	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	1258.900	THPO	-	Target : CHEMBL1293256

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