Tan Lab | DSigDB

Gene Set: D4 : CTD - 6,7-dihydroxyflavone

Collection

D4 : CTD

Chemical Name

6,7-dihydroxyflavone ( From PubChem : 6,7-DIHYDROXYFLAVONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
254.238 g/mol	2	4	2.8712	True

Structure

InChI

InChI=1S/C15H10O4/c16-11-7-14(9-4-2-1-3-5-9)19-15-8-13(18)12(17)6-10(11)15/h1-8,17-18H

InChIKey

Links

Gene (10 / 18)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			CYP1A1		C485383
CTD	decreases(activity)			CYP1A2		C485383
CTD	affects(binding)			CYP1B1		C485383
CTD	decreases(activity)			CYP1B1		C485383
CTD	decreases(reaction)			CYP2C9		C485383
CTD	increases(hydroxylation)			CYP2C9		C485383
CTD	decreases(activity)			CYP3A4		C485383
CTD	increases(degradation)			TP53		C485383
PubChem	Potency	uM	15.849	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	17.783	HPGD	-	GI(Protien) :
PubChem	Potency	uM	3.162	POLK	-	GI(Protien) :
PubChem	Potency	uM	1.995	TP53	-	GI(Protien) :
PubChem	Potency	uM	2.512	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	17782.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	28183.800	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	1995.300	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	2511.900	TP53	-	Target : CHEMBL4096

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