DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

Home

Search Gene

Collection

Browse

Download

Help

DSigDB Home

Search Gene

Collections

Browse Gene Sets

Download

Help

Gene Set: D4 : CTD - 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine

---

Collection	D4 : CTD
Chemical Name	4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine ( From PubChem : NU6027 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 251.285 g/mol 2 7 3.1604 True
Structure
InChI	InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
InChIKey	DGWXOLHKVGDQLN-UHFFFAOYSA-N
Links
Gene (8 / 14) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(activity) ATR C475622 CTD increases(response to substance) ATR C475622 PubChem Potency uM 18.349 ATAD5 - GI(Protien) : PubChem None uM GFER - GI(Protien) : PubChem None uM HCRTR1 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem Potency uM 14.689 MTOR - GI(Protien) : PubChem Potency uM 14.689 MTOR - GI(Protien) : PubChem Potency uM 7.308 TDP1 - GI(Protien) : PubChem Potency uM 11.582 TDP1 - GI(Protien) : ChEMBL Potency nM 18348.900 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 14689.200 MTOR - Target : CHEMBL2842 ChEMBL Potency nM 14689.200 MTOR - Target : CHEMBL2842
Download gene sets	gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).