Tan Lab | DSigDB

Gene Set: D4 : CTD - sunitinib

Collection

D4 : CTD

Chemical Name

sunitinib ( From PubChem : SUNITINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
398.474 g/mol	3	5	3.8638	True

Structure

InChI

InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

InChIKey

WINHZLLDWRZWRT-ATVHPVEESA-N

Links

Gene (41 / 71)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(phosphorylation)			ACACA		C473478
CTD	decreases(activity)			AHR		C473478
CTD	decreases(reaction)			AHR		C473478
CTD	increases(expression)			AHR		C473478
CTD	increases(activity)			AHR		C473478
CTD	decreases(activity)			CACNA1C		C473478
CTD	decreases(reaction)			CASP3		C473478
CTD	increases(cleavage)			CASP3		C473478
CTD	decreases(reaction)			CASP7		C473478
CTD	increases(cleavage)			CASP7		C473478
CTD	decreases(reaction)			CXCL8		C473478
CTD	increases(expression)			CXCL8		C473478
CTD	increases(secretion)			CXCL8		C473478
CTD	decreases(reaction)			CYP1A1		C473478
CTD	increases(expression)			CYP1A1		C473478
CTD	decreases(activity)			CYP1A1		C473478
CTD	increases(activity)			CYP1A1		C473478
CTD	affects(cotreatment)			EIF4EBP1		C473478
CTD	decreases(phosphorylation)			EIF4EBP1		C473478
CTD	increases(expression)			FADS2		C473478
CTD	decreases(phosphorylation)			FLT3		C473478
CTD	decreases(expression)			FLT4		C473478
CTD	increases(expression)			HMGCS1		C473478
CTD	decreases(reaction)			IL6		C473478
CTD	increases(expression)			IL6		C473478
CTD	increases(secretion)			IL6		C473478
CTD	decreases(activity)			KCNH2		C473478
CTD	decreases(phosphorylation)			PDGFRA		C473478
CTD	increases(expression)			PGF		C473478
CTD	decreases(reaction)			PTEN		C473478
CTD	increases(expression)			PTEN		C473478
CTD	increases(secretion)			PTEN		C473478
CTD	increases(response to substance)			PTEN		C473478
CTD	decreases(activity)			RPS6KA1		C473478
CTD	decreases(activity)			RPS6KA3		C473478
CTD	decreases(activity)			SCN5A		C473478
CTD	decreases(localization)			SOX17		C473478
CTD	affects(cotreatment)			TSC2		C473478
CTD	decreases(phosphorylation)			TSC2		C473478
CTD	increases(expression)			VEGFA		C473478
CTD	decreases(expression)			VEGFC		C473478
PubChem	None	uM	9.000	AXL	-	GI(Protien) :
PubChem	None	uM	5.500	BMP2K	-	GI(Protien) :
PubChem	None	uM	2.000	CSF1R	-	GI(Protien) :
PubChem	None	uM		CSNK1G2	-	GI(Protien) :
PubChem	None	uM	1.800	FLT1	-	GI(Protien) :
PubChem	None	uM	0.470	FLT3	-	GI(Protien) :
PubChem	None	uM	0.990	FLT3	-	GI(Protien) :
PubChem	None	uM	2.300	FLT3	-	GI(Protien) :
PubChem	None	uM	2.400	FLT3	-	GI(Protien) :
PubChem	None	uM	4.300	FLT3	-	GI(Protien) :
PubChem	None	uM	1.500	KDR	-	GI(Protien) :
PubChem	None	uM	0.210	KIT	-	GI(Protien) :
PubChem	None	uM	0.280	KIT	-	GI(Protien) :
PubChem	None	uM	0.370	KIT	-	GI(Protien) :
PubChem	None	uM	0.410	KIT	-	GI(Protien) :
PubChem	None	uM		MAP3K5	-	GI(Protien) :
PubChem	None	uM		PAK7	-	GI(Protien) :
PubChem	None	uM	0.790	PDGFRA	-	GI(Protien) :
PubChem	None	uM	0.075	PDGFRB	-	GI(Protien) :
PubChem	None	uM	5.500	PHKG1	-	GI(Protien) :
PubChem	None	uM	5.900	PHKG2	-	GI(Protien) :
PubChem	None	uM		SLK	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	None	uM	1.000	STK17A	-	GI(Protien) :
PubChem	Potency	uM	0.049	YES1		GI(Protien) :
ChEMBL	Inhibition	-		FLT1	-	Target : CHEMBL1868
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		NOS3	-	Target : CHEMBL4803

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