Tan Lab | DSigDB

Gene Set: D4 : CTD - bosutinib

Collection

D4 : CTD

Chemical Name

bosutinib ( From PubChem : BOSUTINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
530.446 g/mol	1	7	5.13918	False(2/4)

Structure

InChI

InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChIKey

UBPYILGKFZZVDX-UHFFFAOYSA-N

Links

Gene (7 / 20)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	decreases(activity)		ABL1		C471992
CTD	decreases(expression)		CCND1		C471992
CTD	affects(cotreatment)		CCND1		C471992
CTD	decreases(expression)		CCND1		C471992
CTD	affects(binding)		CDH1		C471992
CTD	increases(reaction)		CDH1		C471992
CTD	increases(stability)		CDH1		C471992
CTD	affects(localization)		CTNNB1		C471992
CTD	affects(binding)		CTNNB1		C471992
CTD	decreases(reaction)		CTNNB1		C471992
CTD	increases(phosphorylation)		CTNNB1		C471992
CTD	increases(reaction)		CTNNB1		C471992
CTD	decreases(phosphorylation)		CTNNB1		C471992
CTD	increases(stability)		CTNNB1		C471992
CTD	decreases(reaction)		SRC		C471992
CTD	increases(phosphorylation)		SRC		C471992
CTD	decreases(phosphorylation)		SRC		C471992
CTD	affects(binding)		TCF4		C471992
CTD	decreases(reaction)		TCF4		C471992
PubChem	None	uM	SLK	-	GI(Protien) :

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