DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

Home

Search Gene

Collection

Browse

Download

Help

DSigDB Home

Search Gene

Collections

Browse Gene Sets

Download

Help

Gene Set: D4 : CTD - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

---

Collection	D4 : CTD
Chemical Name	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine ( From PubChem : VANDETANIB )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 475.354 g/mol 1 5 5.0151 False(3/4)
Structure
InChI	InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey	UHTHHESEBZOYNR-UHFFFAOYSA-N
Links
Gene (35 / 47) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) ADM C452423 CTD increases(expression) ANGPTL4 C452423 CTD increases(expression) BNIP3L C452423 CTD increases(expression) CALB1 C452423 CTD increases(expression) COL4A3 C452423 CTD increases(expression) DUSP1 C452423 CTD affects(response to substance) EGFR C452423 CTD decreases(activity) EGFR C452423 CTD decreases(phosphorylation) EGFR C452423 CTD increases(expression) ENO2 C452423 CTD increases(expression) FAM13A C452423 CTD increases(expression) HILPDA C452423 CTD increases(expression) HIST1H1C C452423 CTD increases(expression) IGFBP1 C452423 CTD increases(expression) IGFBP3 C452423 CTD increases(expression) INSIG1 C452423 CTD increases(expression) INSIG2 C452423 CTD increases(expression) KDM3A C452423 CTD decreases(expression) MSH3 C452423 CTD increases(expression) MUC1 C452423 CTD increases(expression) NDRG1 C452423 CTD increases(expression) PGK1 C452423 CTD increases(expression) PLOD2 C452423 CTD increases(expression) PRSS2 C452423 CTD decreases(expression) PTMA C452423 CTD decreases(phosphorylation) RET C452423 CTD increases(expression) SCD C452423 CTD increases(expression) SLC2A14 C452423 CTD increases(expression) SLC2A3 C452423 CTD decreases(localization) SOX17 C452423 CTD increases(expression) TSC22D3 C452423 PubChem None uM 4.800 EGFR - GI(Protien) : PubChem None uM 5.900 EGFR - GI(Protien) : PubChem None uM 7.900 EGFR - GI(Protien) : PubChem None uM 8.700 EGFR - GI(Protien) : PubChem None uM 8.900 EGFR - GI(Protien) : PubChem None uM 9.500 EGFR - GI(Protien) : PubChem None uM 9.600 EGFR - GI(Protien) : PubChem Potency uM 26.609 GMNN - GI(Protien) : PubChem Potency uM 12.589 HTT - GI(Protien) : PubChem Potency uM 4.091 MTOR - GI(Protien) : PubChem Potency uM 9.159 MTOR - GI(Protien) : PubChem None uM 4.600 RIPK2 - GI(Protien) : PubChem Potency uM 4.732 TDP1 - GI(Protien) : PubChem Potency uM 4.732 TDP1 - GI(Protien) : PubChem Potency uM 0.061 YES1 GI(Protien) : ChEMBL Potency nM 12589.300 HTT - Target : CHEMBL5514
Download gene sets	gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).