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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one

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Collection	D4 : CTD
Chemical Name	2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one ( From PubChem : PRIMA-1 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 185.22 g/mol 2 4 -1.0576 True
Structure
InChI	InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
InChIKey	RFBVBRVVOPAAFS-UHFFFAOYSA-N
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Gene (13 / 42) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) BAX C451219 CTD increases(expression) BAX C451219 CTD increases(reaction) BAX C451219 CTD affects(reaction) BAX C451219 CTD increases(expression) BBC3 C451219 CTD increases(reaction) BBC3 C451219 CTD decreases(expression) BCL2L1 C451219 CTD increases(activity) CASP3 C451219 CTD increases(cleavage) CASP3 C451219 CTD increases(expression) CDKN1A C451219 CTD increases(expression) CDKN1A C451219 CTD increases(reaction) CDKN1A C451219 CTD affects(reaction) CDKN1A C451219 CTD increases(expression) MDM2 C451219 CTD affects(cotreatment) PMAIP1 C451219 CTD increases(expression) PMAIP1 C451219 CTD affects(binding) TP53 C451219 CTD decreases(reaction) TP53 C451219 CTD increases(localization) TP53 C451219 CTD increases(reaction) TP53 C451219 CTD increases(reaction) TP53 C451219 CTD increases(response to substance) TP53 C451219 CTD increases(activity) TP53 C451219 CTD increases(activity) TP53 C451219 CTD increases(expression) TP53 C451219 CTD affects(reaction) TP53 C451219 CTD increases(activity) TP53 C451219 CTD affects(binding) TP73 C451219 CTD decreases(reaction) TP73 C451219 CTD decreases(reaction) VEGFA C451219 CTD increases(expression) VEGFA C451219 PubChem Potency uM 0.631 CYP2C19 - GI(Protien) : PubChem None uM CYP2C19 - GI(Protien) : PubChem Potency uM 0.063 CYP2C9 - GI(Protien) : PubChem None uM CYP2C9 - GI(Protien) : PubChem Potency uM 2.661 TDP1 - GI(Protien) : PubChem Potency uM 4.611 TDP1 - GI(Protien) : PubChem Potency uM 5.957 TDP1 - GI(Protien) : ChEMBL Potency nM 631.000 CYP2C19 - Target : CHEMBL3622 ChEMBL AC50 nM 630.960 CYP2C19 - Target : CHEMBL3622 ChEMBL AC50 nM 63.100 CYP2C9 - Target : CHEMBL3397 ChEMBL Potency nM 63.100 CYP2C9 - Target : CHEMBL3397
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