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Gene Set: D4 : CTD - 3-(4-methylphenylsulfonyl)-2-propenenitrile

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Collection	D4 : CTD
Chemical Name	3-(4-methylphenylsulfonyl)-2-propenenitrile ( From PubChem : BAY 11-7082 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 207.249 g/mol 0 3 2.88678 True
Structure
InChI	InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChIKey	DOEWDSDBFRHVAP-KRXBUXKQSA-N
Links
Gene (83 / 294) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ABCG2 C434003 CTD increases(expression) ABCG2 C434003 CTD decreases(reaction) ADIPOQ C434003 CTD increases(expression) ADIPOQ C434003 CTD increases(phosphorylation) ADIPOQ C434003 CTD decreases(reaction) ALB C434003 CTD increases(expression) ALB C434003 CTD decreases(reaction) BAG3 C434003 CTD increases(expression) BAG3 C434003 CTD decreases(expression) BCL2 C434003 CTD increases(reaction) BCL2 C434003 CTD decreases(expression) BCL2L1 C434003 CTD increases(expression) BCL2L11 C434003 CTD decreases(expression) BIRC2 C434003 CTD decreases(expression) BIRC2 C434003 CTD decreases(expression) BIRC3 C434003 CTD decreases(expression) BIRC3 C434003 CTD decreases(reaction) CASP3 C434003 CTD decreases(response to substance) CASP3 C434003 CTD increases(cleavage) CASP3 C434003 CTD increases(activity) CASP8 C434003 CTD increases(cleavage) CASP8 C434003 CTD decreases(reaction) CCL2 C434003 CTD increases(expression) CCL2 C434003 CTD decreases(reaction) CCND1 C434003 CTD increases(expression) CCND1 C434003 CTD decreases(expression) CFLAR C434003 CTD decreases(expression) CFLAR C434003 CTD decreases(reaction) CHUK C434003 CTD increases(activity) CHUK C434003 CTD increases(phosphorylation) CHUK C434003 CTD affects(binding) CREBBP C434003 CTD increases(reaction) CREBBP C434003 CTD affects(cotreatment) CSF2 C434003 CTD decreases(activity) CSF2 C434003 CTD decreases(reaction) CXCL8 C434003 CTD increases(secretion) CXCL8 C434003 CTD decreases(reaction) CXCL8 C434003 CTD increases(expression) CXCL8 C434003 CTD decreases(reaction) CXCL8 C434003 CTD increases(expression) CXCL8 C434003 CTD decreases(reaction) CXCL8 C434003 CTD increases(expression) CXCL8 C434003 CTD decreases(reaction) CXCL8 C434003 CTD increases(secretion) CXCL8 C434003 CTD decreases(secretion) CXCL8 C434003 CTD decreases(reaction) EFEMP1 C434003 CTD increases(expression) EFEMP1 C434003 CTD decreases(expression) EFEMP1 C434003 CTD decreases(reaction) EGR1 C434003 CTD increases(expression) EGR1 C434003 CTD affects(binding) EP300 C434003 CTD decreases(reaction) EP300 C434003 CTD increases(reaction) EP300 C434003 CTD decreases(reaction) ERBB2 C434003 CTD decreases(response to substance) ERBB2 C434003 CTD increases(expression) ERBB2 C434003 CTD decreases(reaction) FADD C434003 CTD increases(phosphorylation) FADD C434003 CTD decreases(reaction) FAM168A C434003 CTD decreases(response to substance) FAM168A C434003 CTD increases(cleavage) FAM168A C434003 CTD decreases(reaction) FTH1 C434003 CTD increases(expression) FTH1 C434003 CTD decreases(expression) GPR182 C434003 CTD decreases(reaction) GPR182 C434003 CTD decreases(expression) HAX1 C434003 CTD increases(expression) HDAC1 C434003 CTD affects(cotreatment) HMGB1 C434003 CTD decreases(reaction) HMGB1 C434003 CTD increases(expression) HMGB1 C434003 CTD decreases(reaction) HMOX1 C434003 CTD increases(expression) HMOX1 C434003 CTD decreases(reaction) HSPA9 C434003 CTD increases(expression) HSPA9 C434003 CTD decreases(reaction) HSPA9 C434003 CTD increases(expression) HSPA9 C434003 CTD affects(binding) HSPA9 C434003 CTD increases(reaction) HSPA9 C434003 CTD decreases(reaction) ICAM1 C434003 CTD increases(expression) ICAM1 C434003 CTD decreases(reaction) ICAM1 C434003 CTD increases(expression) ICAM1 C434003 CTD decreases(reaction) ICAM1 C434003 CTD increases(expression) ICAM1 C434003 CTD decreases(reaction) ICAM1 C434003 CTD increases(expression) ICAM1 C434003 CTD decreases(reaction) ICAM1 C434003 CTD increases(expression) ICAM1 C434003 CTD decreases(expression) ICAM1 C434003 CTD decreases(reaction) IFNG C434003 CTD increases(expression) IFNG C434003 CTD decreases(reaction) IGF2 C434003 CTD increases(expression) IGF2 C434003 CTD decreases(response to substance) IGF2 C434003 CTD decreases(reaction) IKBKB C434003 CTD increases(activity) IKBKB C434003 CTD increases(phosphorylation) IKBKB C434003 CTD decreases(activity) IKBKB C434003 CTD decreases(expression) IKBKB C434003 CTD decreases(reaction) IL10 C434003 CTD increases(expression) IL10 C434003 CTD decreases(secretion) IL18 C434003 CTD affects(binding) IL1B C434003 CTD decreases(reaction) IL1B C434003 CTD increases(reaction) IL1B C434003 CTD decreases(reaction) IL1B C434003 CTD increases(expression) IL1B C434003 CTD increases(expression) IL1B C434003 CTD decreases(reaction) IL1B C434003 CTD increases(expression) IL1B C434003 CTD affects(cotreatment) IL1B C434003 CTD decreases(methylation) IL1B C434003 CTD decreases(reaction) IL1B C434003 CTD increases(expression) IL1B C434003 CTD decreases(reaction) IL1B C434003 CTD increases(expression) IL1B C434003 CTD increases(secretion) IL1B C434003 CTD decreases(secretion) IL1B C434003 CTD increases(expression) IL1B C434003 CTD decreases(reaction) IL33 C434003 CTD increases(expression) IL33 C434003 CTD decreases(reaction) IL6 C434003 CTD increases(expression) IL6 C434003 CTD decreases(reaction) IL6 C434003 CTD increases(secretion) IL6 C434003 CTD decreases(reaction) IL6 C434003 CTD increases(expression) IL6 C434003 CTD decreases(reaction) IL6 C434003 CTD increases(expression) IL6 C434003 CTD increases(secretion) IL6 C434003 CTD decreases(expression) IL6 C434003 CTD decreases(secretion) IL6 C434003 CTD decreases(response to substance) IL6 C434003 CTD increases(secretion) IL6 C434003 CTD decreases(expression) IL6 C434003 CTD increases(expression) INSR C434003 CTD affects(cotreatment) MAPK8 C434003 CTD increases(activity) MAPK8 C434003 CTD increases(phosphorylation) MAPK8 C434003 CTD increases(activity) MAPKAPK2 C434003 CTD increases(phosphorylation) MAPKAPK2 C434003 CTD increases(reaction) MAPKAPK2 C434003 CTD decreases(reaction) MIR146A C434003 CTD increases(expression) MIR146A C434003 CTD decreases(expression) MIR200C C434003 CTD decreases(reaction) MIR200C C434003 CTD affects(binding) MIR21 C434003 CTD decreases(reaction) MIR21 C434003 CTD increases(reaction) MIR21 C434003 CTD increases(expression) MIR21 C434003 CTD decreases(expression) NCR1 C434003 CTD decreases(activity) NFKB1 C434003 CTD increases(reaction) NFKB1 C434003 CTD decreases(activity) NFKB1 C434003 CTD affects(binding) NFKB1 C434003 CTD decreases(activity) NFKB1 C434003 CTD decreases(activity) NFKB2 C434003 CTD decreases(reaction) NFKBIA C434003 CTD increases(phosphorylation) NFKBIA C434003 CTD affects(binding) NFKBIA C434003 CTD decreases(reaction) NFKBIA C434003 CTD decreases(reaction) NFKBIA C434003 CTD increases(degradation) NFKBIA C434003 CTD decreases(reaction) NFKBIA C434003 CTD increases(degradation) NFKBIA C434003 CTD affects(cotreatment) NR4A2 C434003 CTD decreases(reaction) NR4A2 C434003 CTD increases(expression) NR4A2 C434003 CTD decreases(reaction) PARP1 C434003 CTD decreases(response to substance) PARP1 C434003 CTD increases(cleavage) PARP1 C434003 CTD increases(activity) PARP1 C434003 CTD increases(cleavage) PARP1 C434003 CTD affects(cotreatment) PARP1 C434003 CTD increases(cleavage) PARP1 C434003 CTD affects(cotreatment) PTGER1 C434003 CTD decreases(reaction) PTGER1 C434003 CTD increases(expression) PTGER1 C434003 CTD decreases(reaction) PTGS2 C434003 CTD increases(expression) PTGS2 C434003 CTD decreases(reaction) PTGS2 C434003 CTD increases(expression) PTGS2 C434003 CTD decreases(reaction) PTGS2 C434003 CTD increases(expression) PTGS2 C434003 CTD affects(cotreatment) RELA C434003 CTD decreases(activity) RELA C434003 CTD affects(binding) RELA C434003 CTD decreases(reaction) RELA C434003 CTD increases(reaction) RELA C434003 CTD affects(localization) RELA C434003 CTD decreases(reaction) RELA C434003 CTD affects(binding) RELA C434003 CTD decreases(reaction) RELA C434003 CTD increases(reaction) RELA C434003 CTD affects(binding) RELA C434003 CTD decreases(reaction) RELA C434003 CTD increases(reaction) RELA C434003 CTD affects(binding) RELA C434003 CTD affects(localization) RELA C434003 CTD decreases(reaction) RELA C434003 CTD decreases(reaction) RELA C434003 CTD increases(expression) RELA C434003 CTD affects(localization) RELA C434003 CTD decreases(reaction) RELA C434003 CTD decreases(activity) RELA C434003 CTD increases(reaction) RELA C434003 CTD affects(localization) RELA C434003 CTD increases(reaction) RELA C434003 CTD affects(binding) RELA C434003 CTD decreases(activity) RELA C434003 CTD decreases(activity) RELA C434003 CTD decreases(reaction) S100B C434003 CTD increases(degradation) S100B C434003 CTD decreases(reaction) SELE C434003 CTD increases(expression) SELE C434003 CTD increases(expression) SIRT1 C434003 CTD decreases(expression) SLC39A8 C434003 CTD decreases(reaction) STAT3 C434003 CTD increases(phosphorylation) STAT3 C434003 CTD decreases(reaction) STS C434003 CTD increases(expression) STS C434003 CTD affects(binding) TERT C434003 CTD decreases(reaction) TERT C434003 CTD increases(reaction) TERT C434003 CTD increases(activity) TERT C434003 CTD decreases(expression) TINF2 C434003 CTD affects(localization) TJP1 C434003 CTD decreases(expression) TJP1 C434003 CTD increases(reaction) TJP1 C434003 CTD affects(cotreatment) TLR4 C434003 CTD decreases(reaction) TLR4 C434003 CTD increases(expression) TLR4 C434003 CTD decreases(reaction) TNF C434003 CTD increases(expression) TNF C434003 CTD affects(localization) TNF C434003 CTD decreases(reaction) TNF C434003 CTD decreases(reaction) TNF C434003 CTD increases(degradation) TNF C434003 CTD decreases(reaction) TNF C434003 CTD increases(expression) TNF C434003 CTD increases(secretion) TNF C434003 CTD increases(expression) TNF C434003 CTD decreases(reaction) TNF C434003 CTD increases(expression) TNF C434003 CTD increases(phosphorylation) TNF C434003 CTD decreases(secretion) TNF C434003 CTD decreases(phosphorylation) TP53 C434003 CTD decreases(reaction) TP53 C434003 CTD affects(binding) TP53 C434003 CTD increases(reaction) TP53 C434003 CTD affects(localization) TP53 C434003 CTD increases(reaction) TP53 C434003 CTD increases(phosphorylation) TP53 C434003 CTD decreases(reaction) VCAM1 C434003 CTD increases(expression) VCAM1 C434003 CTD decreases(reaction) VCAM1 C434003 CTD increases(expression) VCAM1 C434003 CTD affects(cotreatment) XIAP C434003 CTD decreases(expression) XIAP C434003 CTD decreases(expression) XIAP C434003 CTD increases(reaction) XIAP C434003 CTD decreases(expression) XIAP C434003 CTD decreases(expression) XIAP C434003 CTD increases(expression) XIAP C434003 CTD decreases(response to substance) XIAP C434003 PubChem Potency uM 0.056 ALDH1A1 - GI(Protien) : PubChem Potency uM 0.063 ALDH1A1 - GI(Protien) : PubChem Potency uM 20.588 ATAD5 - GI(Protien) : PubChem Potency uM 10.000 ATXN2 - GI(Protien) : PubChem Potency uM 10.000 ATXN2 - GI(Protien) : PubChem Potency uM 39.811 CBX1 - GI(Protien) : PubChem Potency uM 12.589 DRD1 - GI(Protien) : PubChem Potency uM 1.122 EHMT2 - GI(Protien) : PubChem Potency uM 1.585 EHMT2 - GI(Protien) : PubChem Potency uM 12.589 GLS - GI(Protien) : PubChem Potency uM 22.387 KAT2A - GI(Protien) : PubChem None uM MITF - GI(Protien) : PubChem Potency uM 5.973 RGS4 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 0.651 TDP1 - GI(Protien) : PubChem Potency uM 1.300 TDP1 - GI(Protien) : PubChem Potency uM 3.162 VDR - GI(Protien) : PubChem Potency uM 5.623 VDR - GI(Protien) : PubChem Potency uM 11.220 VDR - GI(Protien) : ChEMBL Potency nM 63.100 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 56.200 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 20587.800 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 39810.700 CBX1 - Target : CHEMBL1741193 ChEMBL Activity - CDK1 - Target : CHEMBL308 ChEMBL Potency nM 12589.300 DRD1 - Target : CHEMBL2056 ChEMBL Potency nM 1122.000 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 1584.900 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 22387.200 KAT2A - Target : CHEMBL5501
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