Tan Lab | DSigDB

Gene Set: D4 : CTD - Canertinib

Collection

D4 : CTD

Chemical Name

Canertinib ( From PubChem : CANERTINIB DIHYDROCHLORIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
558.86 g/mol	4	7	6.0794	False(2/4)

Structure

InChI

InChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H

InChIKey

JZZFDCXSFTVOJY-UHFFFAOYSA-N

Links

Gene (8 / 23)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	decreases(expression)		CXCL8		C420268
CTD	decreases(secretion)		CXCL8		C420268
CTD	decreases(reaction)		EGF		C420268
CTD	increases(phosphorylation)		EGF		C420268
CTD	decreases(reaction)		EGFR		C420268
CTD	increases(phosphorylation)		EGFR		C420268
CTD	decreases(activity)		EGFR		C420268
CTD	decreases(phosphorylation)		EGFR		C420268
CTD	decreases(reaction)		ERBB2		C420268
CTD	increases(phosphorylation)		ERBB2		C420268
CTD	decreases(reaction)		MAPK1		C420268
CTD	increases(phosphorylation)		MAPK1		C420268
CTD	decreases(reaction)		MAPK3		C420268
CTD	increases(phosphorylation)		MAPK3		C420268
CTD	decreases(expression)		VEGFA		C420268
CTD	decreases(secretion)		VEGFA		C420268
ChEMBL	Activity	-	BMX	-	Target : CHEMBL3834
ChEMBL	Activity	-	BMX	-	Target : CHEMBL3834
ChEMBL	Inhibition	-	EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-	EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-	EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-	EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-	EGFR	-	Target : CHEMBL203

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