Tan Lab | DSigDB

Gene Set: D4 : CTD - alfacalcidol

Collection

D4 : CTD

Chemical Name

alfacalcidol ( From PubChem : ALFACALCIDOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
400.637 g/mol	2	2	6.5898	False(3/4)

Structure

InChI

InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3

InChIKey

OFHCOWSQAMBJIW-UHFFFAOYSA-N

Links

Gene (15 / 26)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ALB		C008088
CTD	affects(cotreatment)			CD14		C008088
CTD	increases(expression)			CD14		C008088
CTD	increases(hydroxylation)			CYP3A4		C008088
CTD	affects(binding)			MED1		C008088
CTD	increases(reaction)			MED1		C008088
CTD	affects(binding)			NCOA1		C008088
CTD	increases(reaction)			NCOA1		C008088
CTD	affects(binding)			RXRA		C008088
CTD	increases(reaction)			RXRA		C008088
CTD	affects(response to substance)			TGFB1		C008088
CTD	decreases(expression)			TLR2		C008088
CTD	decreases(expression)			TNFRSF1B		C008088
CTD	increases(expression)			TSHB		C008088
CTD	increases(reaction)			TSHB		C008088
CTD	affects(binding)			VDR		C008088
CTD	increases(reaction)			VDR		C008088
CTD	increases(activity)			VDR		C008088
PubChem	Ratio Potency (uM)	uM	8.988	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	31.017	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	20.122	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	29.849	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.485	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	10.593	TDP1	-	GI(Protien) :

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