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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione

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Collection	D4 : CTD
Chemical Name	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione ( From PubChem : SB 415286 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 359.721 g/mol 3 5 3.3584 True
Structure
InChI	InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChIKey	PQCXVIPXISBFPN-UHFFFAOYSA-N
Links
Gene (40 / 77) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) CASP8 C417520 CTD increases(activity) CASP8 C417520 CTD decreases(reaction) CASP8 C417520 CTD increases(activity) CASP8 C417520 CTD decreases(activity) CCND1 C417520 CTD decreases(expression) CCND1 C417520 CTD decreases(reaction) CCND1 C417520 CTD increases(phosphorylation) CREB1 C417520 CTD affects(localization) FAS C417520 CTD decreases(reaction) FAS C417520 CTD increases(expression) FAS C417520 CTD decreases(activity) GSK3B C417520 CTD decreases(expression) GSK3B C417520 CTD decreases(reaction) GSK3B C417520 CTD decreases(reaction) GYS1 C417520 CTD increases(phosphorylation) GYS1 C417520 CTD decreases(phosphorylation) RPS6KB1 C417520 CTD decreases(reaction) RPS6KB1 C417520 PubChem Potency uM 28.184 ALDH1A1 - GI(Protien) : PubChem Potency uM 50.119 BAZ2B - GI(Protien) : PubChem Potency uM 35.481 CBX1 - GI(Protien) : PubChem AC50_uM uM 5.559 CDK5 - GI(Protien) : PubChem None uM CDK5 - GI(Protien) : PubChem AC50_uM uM 5.559 CDK5R1 - GI(Protien) : PubChem None uM CDK5R1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP3A4 - GI(Protien) : PubChem Potency uM 5.173 DRD1 - GI(Protien) : PubChem None uM DRD1 - GI(Protien) : PubChem Potency uM 1.500 EHMT2 - GI(Protien) : PubChem Potency uM 3.548 EHMT2 - GI(Protien) : PubChem IC50 uM EIF4H - GI(Protien) : PubChem Potency uM 18.888 FEN1 - GI(Protien) : PubChem Potency uM 18.888 FEN1 - GI(Protien) : PubChem None uM GALR3 - GI(Protien) : PubChem None uM GFER - GI(Protien) : PubChem Potency uM 10.000 GLS - GI(Protien) : PubChem None uM GSK3A - GI(Protien) : PubChem EC50_uM uM 0.239 GSK3B - GI(Protien) : PubChem None uM GSK3B - GI(Protien) : PubChem None uM GSTO1 - GI(Protien) : PubChem None uM GSTO1 - GI(Protien) : PubChem Potency uM 12.589 HIF1A - GI(Protien) : PubChem None uM HTT - GI(Protien) : PubChem Potency uM 7.943 MAPT - GI(Protien) : PubChem None uM MCL1 - GI(Protien) : PubChem Potency uM 56.234 MPHOSPH8 - GI(Protien) : PubChem IC50 uM PABPC1 - GI(Protien) : PubChem None uM PADI4 - GI(Protien) : PubChem None uM PLA2G7 - GI(Protien) : PubChem Potency uM 11.220 POLB - GI(Protien) : PubChem Potency uM 28.184 POLI - GI(Protien) : PubChem Potency uM 11.220 POLK - GI(Protien) : PubChem None uM PSIP1 - GI(Protien) : PubChem Potency uM 11.917 RGS4 - GI(Protien) : PubChem Potency uM 7.308 TDP1 - GI(Protien) : PubChem Potency uM 26.609 TDP1 - GI(Protien) : PubChem Potency uM 26.609 TDP1 - GI(Protien) : PubChem None uM TRA - GI(Protien) : PubChem Potency uM 44.668 VDR - GI(Protien) : ChEMBL Potency nM 28183.800 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 50118.700 BAZ2B - Target : CHEMBL1741220 ChEMBL Potency nM 35481.300 CBX1 - Target : CHEMBL1741193 ChEMBL AC50 nM 5559.000 CDK5 - Target : CHEMBL1907600 ChEMBL AC50 nM 5559.000 CDK5R1 - Target : CHEMBL1907600 ChEMBL AC50 nM 19952.600 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 5173.200 DRD1 - Target : CHEMBL2056 ChEMBL Potency nM 1500.300 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 3548.100 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 18887.600 FEN1 - Target : CHEMBL5027 ChEMBL Potency nM 12589.300 HIF1A - Target : CHEMBL4261 ChEMBL Potency nM 3162.300 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 12589.300 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 199.500 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 7943.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 56234.100 MPHOSPH8 - Target : CHEMBL1741210 ChEMBL Potency nM 11220.200 POLB - Target : CHEMBL2392
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