Tan Lab | DSigDB

Gene Set: D4 : CTD - 1,2,4-trihydroxy-9,10-anthracenedione

Collection

D4 : CTD

Chemical Name

1,2,4-trihydroxy-9,10-anthracenedione ( From PubChem : PURPURIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
256.21 g/mol	3	5	1.5788	True

Structure

InChI

InChI=1S/C14H8O5/c15-8-5-9(16)14(19)11-10(8)12(17)6-3-1-2-4-7(6)13(11)18/h1-5,15-16,19H

InChIKey

BBNQQADTFFCFGB-UHFFFAOYSA-N

Links

Gene (42 / 64)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			CYP1A1		C410870
CTD	increases(expression)			CYP1A1		C511975
CTD	decreases(activity)			CYP1A2		C410870
CTD	decreases(activity)			CYP1B1		C410870
CTD	increases(expression)			CYP1B1		C511975
CTD	decreases(activity)			CYP2A6		C410870
CTD	decreases(activity)			CYP2E1		C410870
PubChem	AhR Potency (uM)	uM	7.406	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.871	AHR	-	GI(Protien) :
PubChem	Potency	uM	5.012	ALOX15	-	GI(Protien) :
PubChem	None	uM		CASP6	-	GI(Protien) :
PubChem	Potency	uM	11.220	CBX1	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		DAGLB	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	37.933	FEN1	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	Potency	uM	25.119	HPGD	-	GI(Protien) :
PubChem	Potency	uM	28.184	HPGD	-	GI(Protien) :
PubChem	Potency	uM	9.200	IDH1	-	GI(Protien) :
PubChem	Potency	uM	7.943	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	31.623	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	5.012	MAPT	-	GI(Protien) :
PubChem	None	uM		MMP14	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.324	NFE2L2	-	GI(Protien) :
PubChem	None	uM		PADI4	-	GI(Protien) :
PubChem	None	uM		PAFAH1B3	-	GI(Protien) :
PubChem	None	uM		PAFAH1B3	-	GI(Protien) :
PubChem	Potency	uM	26.855	PIN1	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	26.680	PLK1	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLH	-	GI(Protien) :
PubChem	Potency	uM	42.562	POLH	-	GI(Protien) :
PubChem	Potency	uM	79.433	POLI	-	GI(Protien) :
PubChem	Potency	uM	3.981	POLK	-	GI(Protien) :
PubChem	Potency	uM	7.080	POLK	-	GI(Protien) :
PubChem	Potency	uM	50.119	POLK	-	GI(Protien) :
PubChem	Potency	uM	75.193	POLK		GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		RNASEH1	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	Potency	uM	25.119	USP1	-	GI(Protien) :
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	5011.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	39810.700	BRCA1	-	Target : CHEMBL5990
ChEMBL	Potency	nM	28183.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	25118.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	3162.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	7943.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	7943.300	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	22387.200	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	15848.900	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	22387.200	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	31622.800	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	12589.300	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	5011.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3981.100	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	6309.600	RECQL	-	Target : CHEMBL1293236

Download gene sets

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