Tan Lab | DSigDB

Gene Set: D4 : CTD - 25-hydroxycholesterol

Collection

D4 : CTD

Chemical Name

25-hydroxycholesterol ( From PubChem : 25-HYDROXYCHOLESTEROL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
402.653 g/mol	2	2	6.5036	False(3/4)

Structure

InChI

InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1

InChIKey

INBGSXNNRGWLJU-ZHHJOTBYSA-N

Links

Gene (25 / 73)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	affects(binding)		ABCA1		C007997
CTD	increases(activity)		ABCA1		C007997
CTD	increases(expression)		ABCA1		C007997
CTD	affects(cotreatment)		ABCA1		C007997
CTD	increases(expression)		ABCA1		C007997
CTD	increases(reaction)		ABCA1		C007997
CTD	affects(cotreatment)		ADIPOR1		C007997
CTD	decreases(expression)		ADIPOR1		C007997
CTD	increases(expression)		CXCL8		C007997
CTD	increases(secretion)		CXCL8		C007997
CTD	increases(chemical synthesis)		CYP27A1		C007997
CTD	increases(metabolic processing)		CYP27A1		C007997
CTD	increases(metabolic processing)		CYP7A1		C007997
CTD	affects(binding)		ESR1		C007997
CTD	decreases(activity)		ESR1		C007997
CTD	decreases(reaction)		ESR1		C007997
CTD	increases(activity)		ESR1		C007997
CTD	affects(binding)		ESR2		C007997
CTD	decreases(activity)		ESR2		C007997
CTD	decreases(reaction)		ESR2		C007997
CTD	increases(activity)		ESR2		C007997
CTD	decreases(reaction)		FADS1		C007997
CTD	increases(expression)		FADS1		C007997
CTD	decreases(expression)		FADS1		C007997
CTD	affects(cotreatment)		HMGCR		C007997
CTD	increases(ubiquitination)		HMGCR		C007997
CTD	decreases(activity)		HMGCR		C007997
CTD	decreases(activity)		HMGCR		C007997
CTD	decreases(reaction)		HMGCR		C007997
CTD	increases(reaction)		IL1B		C007997
CTD	increases(secretion)		IL1B		C007997
CTD	increases(expression)		IL1B		C007997
CTD	decreases(reaction)		IL6		C007997
CTD	increases(secretion)		IL6		C007997
CTD	decreases(reaction)		LDLR		C007997
CTD	increases(activity)		LDLR		C007997
CTD	increases(cleavage)		LDLR		C007997
CTD	increases(expression)		LDLR		C007997
CTD	decreases(activity)		LPL		C007997
CTD	decreases(expression)		LPL		C007997
CTD	increases(expression)		NOS2		C007997
CTD	decreases(expression)		NOS3		C007997
CTD	affects(binding)		NR1H3		C007997
CTD	increases(activity)		NR1H3		C007997
CTD	increases(expression)		NR1H3		C007997
CTD	increases(transport)		NR1H3		C007997
CTD	increases(reaction)		NR1H3		C007997
CTD	increases(expression)		NR5A1		C007997
CTD	increases(reaction)		NR5A1		C007997
CTD	increases(activity)		NR5A1		C007997
CTD	affects(binding)		PPARA		C007997
CTD	increases(activity)		PPARA		C007997
CTD	increases(expression)		PPARA		C007997
CTD	increases(reaction)		PPARA		C007997
CTD	increases(transport)		PPARA		C007997
CTD	affects(binding)		PPARG		C007997
CTD	increases(activity)		PPARG		C007997
CTD	increases(expression)		PPARG		C007997
CTD	increases(reaction)		PPARG		C007997
CTD	increases(transport)		PPARG		C007997
CTD	affects(binding)		RORC		C007997
CTD	decreases(reaction)		RORC		C007997
CTD	decreases(reaction)		SREBF2		C007997
CTD	increases(activity)		SREBF2		C007997
CTD	increases(cleavage)		SREBF2		C007997
CTD	increases(expression)		SREBF2		C007997
CTD	decreases(activity)		SREBF2		C007997
CTD	decreases(reaction)		SREBF2		C007997
CTD	increases(expression)		STAR		C007997
CTD	increases(reaction)		STAR		C007997
CTD	increases(expression)		TNFSF15		C007997
CTD	increases(expression)		VCAM1		C007997
ChEMBL	Activity	-	NPC1	-	Target : CHEMBL1293277

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