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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane

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Collection	D4 : CTD
Chemical Name	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane ( From PubChem : HYDROXYCHLOR )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 317.595 g/mol 2 2 4.5999 True
Structure
InChI	InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
InChIKey	IUGDILGOLSSKNE-UHFFFAOYSA-N
Links
Gene (19 / 78) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD affects(binding) AR C404910 CTD decreases(activity) AR C404910 CTD affects(binding) AR C404910 CTD decreases(reaction) AR C404910 CTD increases(activity) AR C404910 CTD decreases(reaction) AR C404910 CTD increases(activity) AR C404910 CTD affects(binding) AR C404910 CTD decreases(reaction) AR C404910 CTD increases(activity) AR C404910 CTD decreases(activity) AR C404910 CTD increases(expression) CXCL12 C404910 CTD affects(response to substance) CXCL12 C404910 CTD decreases(reaction) CXCL12 C404910 CTD decreases(response to substance) CXCR4 C404910 CTD decreases(activity) CYP17A1 C404910 CTD affects(binding) CYP19A1 C404910 CTD decreases(activity) CYP19A1 C404910 CTD decreases(reaction) CYP19A1 C404910 CTD increases(metabolic processing) CYP19A1 C404910 CTD decreases(expression) CYP19A1 C404910 CTD affects(binding) ESR1 C404910 CTD increases(activity) ESR1 C404910 CTD affects(binding) ESR1 C404910 CTD affects(binding) ESR1 C404910 CTD decreases(reaction) ESR1 C404910 CTD increases(activity) ESR1 C404910 CTD increases(reaction) ESR1 C404910 CTD increases(activity) ESR1 C404910 CTD decreases(reaction) ESR1 C404910 CTD increases(expression) ESR1 C404910 CTD affects(binding) ESR2 C404910 CTD decreases(activity) ESR2 C404910 CTD affects(binding) ESR2 C404910 CTD increases(activity) ESR2 C404910 CTD affects(binding) ESR2 C404910 CTD decreases(reaction) ESR2 C404910 CTD increases(activity) ESR2 C404910 CTD increases(expression) GREB1 C404910 CTD decreases(reaction) GREB1 C404910 CTD decreases(activity) HSD11B1 C404910 CTD decreases(activity) HSD11B2 C404910 CTD decreases(activity) HSD17B3 C404910 CTD decreases(reaction) HSD17B3 C404910 CTD increases(expression) PGR C404910 CTD decreases(reaction) PGR C404910 CTD increases(expression) PRSS23 C404910 CTD decreases(reaction) PRSS23 C404910 CTD increases(expression) TFF1 C404910 CTD decreases(reaction) TFF1 C404910 CTD increases(expression) WISP2 C404910 CTD decreases(reaction) WISP2 C404910 PubChem Potency-Replicate_1 uM 6.917 AR - GI(Protien) : PubChem Ratio Potency (uM) uM 7.761 AR - GI(Protien) : PubChem Ratio Potency (uM) uM 8.350 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 9.735 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 30.638 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 48.360 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 61.131 CYP19A1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.077 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.121 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.593 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.614 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.804 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.977 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 44.970 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 48.558 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 54.261 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 54.941 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 57.476 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 57.090 HSPB1 - GI(Protien) : PubChem Ratio Potency (uM) uM 10.068 NFE2L2 - GI(Protien) : PubChem Potency uM 54.483 NFE2L2 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.872 NR3C1 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 6.917 PPARG - GI(Protien) : PubChem None uM PPARG - GI(Protien) :
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