Tan Lab | DSigDB

Gene Set: D4 : CTD - desloratadine

Collection

D4 : CTD

Chemical Name

desloratadine ( From PubChem : DESLORATADINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
310.821 g/mol	1	2	4.3477	True

Structure

InChI

InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChIKey

Links

Gene (16 / 23)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(export)			ABCB1		C121345
CTD	decreases(reaction)			ABCC2		C121345
CTD	increases(export)			ABCC2		C121345
CTD	affects(cotreatment)			CXCL8		C121345
CTD	decreases(expression)			CXCL8		C121345
CTD	affects(chemical synthesis)			CYP2D6		C121345
CTD	affects(binding)			HRH1		C121345
CTD	affects(cotreatment)			IL5		C121345
CTD	decreases(expression)			IL5		C121345
CTD	decreases(reaction)			SLC22A2		C121345
CTD	increases(uptake)			SLC22A2		C121345
PubChem	AR Potency (uM)	uM	28.726	AR	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	PPARD	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	Potency	uM	6.513	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.837	TDP1	-	GI(Protien) :

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