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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide

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Collection	D4 : CTD
Chemical Name	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide ( From PubChem : CI-1040 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 478.66 g/mol 2 3 5.5017 False(3/4)
Structure
InChI	InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey	GFMMXOIFOQCCGU-UHFFFAOYSA-N
Links
Gene (27 / 74) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) AHR C120227 CTD affects(cotreatment) AIFM1 C120227 CTD affects(localization) AIFM1 C120227 CTD increases(cleavage) CASP3 C120227 CTD affects(cotreatment) CASP3 C120227 CTD increases(cleavage) CASP3 C120227 CTD affects(cotreatment) CASP9 C120227 CTD increases(cleavage) CASP9 C120227 CTD increases(expression) CAV1 C120227 CTD decreases(reaction) CD38 C120227 CTD increases(expression) CD38 C120227 CTD decreases(phosphorylation) EGFR C120227 CTD decreases(reaction) ITGAM C120227 CTD increases(expression) ITGAM C120227 CTD decreases(activity) MAP2K1 C120227 CTD decreases(reaction) MAPK1 C120227 CTD increases(phosphorylation) MAPK1 C120227 CTD decreases(reaction) MAPK1 C120227 CTD increases(phosphorylation) MAPK1 C120227 CTD decreases(reaction) MAPK1 C120227 CTD increases(activity) MAPK1 C120227 CTD decreases(activity) MAPK1 C120227 CTD decreases(expression) MAPK1 C120227 CTD decreases(phosphorylation) MAPK1 C120227 CTD affects(cotreatment) MAPK1 C120227 CTD decreases(phosphorylation) MAPK1 C120227 CTD decreases(reaction) MAPK3 C120227 CTD increases(phosphorylation) MAPK3 C120227 CTD decreases(reaction) MAPK3 C120227 CTD increases(activity) MAPK3 C120227 CTD decreases(activity) MAPK3 C120227 CTD decreases(expression) MAPK3 C120227 CTD decreases(phosphorylation) MAPK3 C120227 CTD affects(cotreatment) MAPK3 C120227 CTD decreases(phosphorylation) MAPK3 C120227 CTD affects(cotreatment) MCL1 C120227 CTD decreases(response to substance) MCL1 C120227 CTD decreases(expression) MCL1 C120227 CTD affects(cotreatment) MKI67 C120227 CTD decreases(expression) MKI67 C120227 CTD decreases(expression) MMP1 C120227 CTD decreases(reaction) NFE2L2 C120227 CTD increases(activity) NFE2L2 C120227 CTD increases(expression) NFE2L2 C120227 CTD decreases(reaction) NQO1 C120227 CTD increases(activity) NQO1 C120227 CTD increases(expression) NQO1 C120227 CTD affects(cotreatment) PECAM1 C120227 CTD decreases(expression) PECAM1 C120227 CTD decreases(reaction) RARB C120227 CTD increases(expression) RARB C120227 CTD affects(binding) TP53AIP1 C120227 CTD affects(cotreatment) TP53AIP1 C120227 CTD increases(reaction) TP53AIP1 C120227 CTD increases(expression) TP53AIP1 C120227 CTD affects(cotreatment) TP53AIP1 C120227 CTD increases(expression) TP53AIP1 C120227 CTD affects(expression) TP73 C120227 CTD decreases(reaction) TP73 C120227 CTD increases(expression) TP73 C120227 CTD increases(expression) TP73 C120227 CTD increases(activity) TP73 C120227 CTD increases(phosphorylation) TP73 C120227 CTD affects(binding) TP73 C120227 CTD affects(cotreatment) TP73 C120227 CTD increases(reaction) TP73 C120227 PubChem Potency-Replicate_1 uM 3.790 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 17.593 ESR1 - GI(Protien) : PubChem None uM NR1H4 - GI(Protien) : PubChem Potency-Replicate_1 uM 10.682 NR3C1 - GI(Protien) : PubChem None uM PPARD - GI(Protien) : PubChem None uM PPARG - GI(Protien) : PubChem Potency uM 14.963 TDP1 - GI(Protien) : ChEMBL Inhibition - RPS6KA1 - Target : CHEMBL2553
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