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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 18alpha-glycyrrhetinic acid

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Collection	D4 : CTD
Chemical Name	18alpha-glycyrrhetinic acid ( From PubChem : ENOXOLONE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 470.684 g/mol 2 4 6.4126 False(3/4)
Structure
InChI	InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)
InChIKey	MPDGHEJMBKOTSU-UHFFFAOYSA-N
Links
Gene (24 / 45) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD affects(activity) AKR1C3 C119129 CTD decreases(activity) HSD11B1 C119129 CTD decreases(activity) HSD11B2 C119129 CTD decreases(reaction) MMP9 C119129 CTD increases(activity) MMP9 C119129 CTD increases(expression) MMP9 C119129 CTD decreases(expression) NFKB1 C119129 CTD decreases(reaction) NFKB1 C119129 CTD decreases(reaction) NFKBIA C119129 CTD increases(degradation) NFKBIA C119129 CTD increases(phosphorylation) NFKBIA C119129 CTD decreases(expression) RELA C119129 CTD decreases(reaction) RELA C119129 CTD decreases(expression) TNF C119129 CTD decreases(reaction) TNF C119129 CTD increases(activity) TNF C119129 CTD increases(expression) TNF C119129 CTD increases(secretion) TNF C119129 CTD increases(degradation) TNF C119129 CTD increases(phosphorylation) TNF C119129 CTD decreases(reaction) VEGFA C119129 CTD increases(expression) VEGFA C119129 CTD increases(secretion) VEGFA C119129 PubChem Potency uM 26.609 GMNN - GI(Protien) : PubChem None uM AKR1C4 - GI(Protien) : PubChem None uM HSD11B1 - GI(Protien) : PubChem Ratio Potency (uM) uM 43.156 HSPB1 - GI(Protien) : PubChem Potency-Replicate_1 uM 21.314 NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 23.915 NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 43.156 NR3C1 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : PubChem Potency uM 33.587 POLK - GI(Protien) : PubChem Potency uM 2.372 TDP1 - GI(Protien) : PubChem Potency uM 7.499 TDP1 - GI(Protien) : PubChem None uM AKR1C4 - GI(Protien) : ChEMBL Inhibition - AKR1B10 - Target : CHEMBL5983 ChEMBL Inhibition - CYP2C19 - Target : CHEMBL3622 ChEMBL Inhibition - CYP2C9 - Target : CHEMBL3397 ChEMBL Inhibition - CYP2D6 - Target : CHEMBL289 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340 ChEMBL Inhibition - CYP3A4 - Target : CHEMBL340 ChEMBL Activity - PPARG - Target : CHEMBL235 ChEMBL Inhibition - PRKCA - Target : CHEMBL3137267 ChEMBL Inhibition - PRKCB - Target : CHEMBL3137267 ChEMBL Activity - PRKCD - Target : CHEMBL2996
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