Tan Lab | DSigDB

Gene Set: D4 : CTD - entinostat

Collection

D4 : CTD

Chemical Name

entinostat ( From PubChem : ENTINOSTAT )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
376.409 g/mol	3	7	4.3876	True

Structure

InChI

InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChIKey

INVTYAOGFAGBOE-UHFFFAOYSA-N

Links

Gene (35 / 75)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			AIFM1		C118739
CTD	increases(secretion)			AIFM1		C118739
CTD	affects(cotreatment)			CCNA2		C118739
CTD	decreases(expression)			CCNA2		C118739
CTD	affects(cotreatment)			CCND1		C118739
CTD	decreases(expression)			CCND1		C118739
CTD	decreases(phosphorylation)			CCND1		C118739
CTD	increases(degradation)			CCND1		C118739
CTD	affects(cotreatment)			CCNE1		C118739
CTD	decreases(expression)			CCNE1		C118739
CTD	decreases(reaction)			CDKN1A		C118739
CTD	increases(expression)			CDKN1A		C118739
CTD	increases(reaction)			CDKN1A		C118739
CTD	decreases(expression)			CDKN1A		C118739
CTD	affects(cotreatment)			CDKN1B		C118739
CTD	decreases(expression)			CDKN1B		C118739
CTD	affects(cotreatment)			CYCS		C118739
CTD	increases(secretion)			CYCS		C118739
CTD	affects(cotreatment)			DIABLO		C118739
CTD	increases(secretion)			DIABLO		C118739
CTD	increases(expression)			ENO2		C118739
CTD	affects(binding)			EP300		C118739
CTD	increases(reaction)			EP300		C118739
CTD	affects(cotreatment)			HIST3H3		C118739
CTD	increases(acetylation)			HIST3H3		C118739
CTD	affects(cotreatment)			HIST4H4		C118739
CTD	increases(acetylation)			HIST4H4		C118739
CTD	increases(secretion)			IFNG		C118739
CTD	affects(expression)			MAGEA9		C118739
CTD	affects(reaction)			MAGEA9		C118739
CTD	increases(expression)			MAP1LC3B		C118739
CTD	affects(cotreatment)			MAPK8		C118739
CTD	increases(activity)			MAPK8		C118739
CTD	increases(phosphorylation)			MAPK8		C118739
CTD	affects(cotreatment)			MCL1		C118739
CTD	increases(expression)			MCL1		C118739
CTD	decreases(secretion)			MMP2		C118739
CTD	decreases(secretion)			MMP9		C118739
CTD	increases(expression)			MT3		C118739
CTD	increases(expression)			MT3		C118739
CTD	increases(reaction)			MT3		C118739
CTD	decreases(reaction)			NOS2		C118739
CTD	increases(expression)			NOS2		C118739
CTD	decreases(reaction)			PTGS2		C118739
CTD	increases(expression)			PTGS2		C118739
CTD	affects(localization)			RELA		C118739
CTD	decreases(reaction)			RELA		C118739
CTD	affects(localization)			RELA		C118739
CTD	decreases(reaction)			RELA		C118739
CTD	affects(binding)			RELA		C118739
CTD	increases(reaction)			RELA		C118739
CTD	increases(acetylation)			RELA		C118739
CTD	increases(expression)			TNFSF9		C118739
CTD	affects(cotreatment)			TNFSF9		C118739
CTD	increases(reaction)			TNFSF9		C118739
CTD	increases(expression)			TP63		C118739
CTD	decreases(secretion)			VEGFA		C118739
CTD	affects(cotreatment)			XIAP		C118739
CTD	decreases(expression)			XIAP		C118739
CTD	affects(cotreatment)			XIAP		C118739
CTD	increases(expression)			XIAP		C118739
CTD	decreases(response to substance)			XIAP		C118739
PubChem	Potency	uM	2.810	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	15.410	YES1		GI(Protien) :
ChEMBL	Inhibition	-		CFTR	-	Target : CHEMBL4051
ChEMBL	Activity	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC2	-	Target : CHEMBL1937
ChEMBL	Activity	-		HDAC4	-	Target : CHEMBL3524
ChEMBL	Inhibition	-		HDAC4	-	Target : CHEMBL3524
ChEMBL	Activity	-		HDAC6	-	Target : CHEMBL1865
ChEMBL	Inhibition	-		HDAC7	-	Target : CHEMBL2716
ChEMBL	Inhibition	-		HDAC7	-	Target : CHEMBL2716

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