Tan Lab | DSigDB

Gene Set: D4 : CTD - rofecoxib

Collection

D4 : CTD

Chemical Name

rofecoxib ( From PubChem : ROFECOXIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
314.356 g/mol	0	4	3.6385	True

Structure

InChI

InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

InChIKey

RZJQGNCSTQAWON-UHFFFAOYSA-N

Links

Gene (99 / 117)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(expression)			ADAMTS8		C116926
CTD	affects(expression)			ADGRF1		C116926
CTD	affects(expression)			ADGRG6		C116926
CTD	affects(expression)			ALOX15B		C116926
CTD	decreases(expression)			ANGPT1		C116926
CTD	decreases(expression)			ANGPTL1		C116926
CTD	affects(expression)			ANXA1		C116926
CTD	increases(expression)			ANXA3		C116926
CTD	decreases(expression)			ANXA9		C116926
CTD	decreases(expression)			AOX1		C116926
CTD	decreases(expression)			ARHGAP29		C116926
CTD	affects(expression)			C2CD4A		C116926
CTD	increases(expression)			C3		C116926
CTD	decreases(expression)			CACNA2D3		C116926
CTD	increases(expression)			CCL2		C116926
CTD	affects(expression)			CDH2		C116926
CTD	increases(expression)			CDH3		C116926
CTD	affects(expression)			CDSN		C116926
CTD	affects(expression)			CEACAM1		C116926
CTD	increases(expression)			CLU		C116926
CTD	decreases(expression)			COL14A1		C116926
CTD	decreases(expression)			COLEC12		C116926
CTD	increases(expression)			CRISP3		C116926
CTD	affects(expression)			CX3CL1		C116926
CTD	affects(expression)			CXCL1		C116926
CTD	increases(expression)			CXCL8		C116926
CTD	decreases(reaction)			CYP1A2		C116926
CTD	increases(metabolic processing)			CYP1A2		C116926
CTD	decreases(reaction)			CYP1A2		C116926
CTD	increases(metabolic processing)			CYP1A2		C116926
CTD	decreases(activity)			CYP1A2		C116926
CTD	increases(expression)			DEFB4A		C116926
CTD	affects(expression)			DSC1		C116926
CTD	decreases(reaction)			EDNRB		C116926
CTD	increases(activity)			EDNRB		C116926
CTD	decreases(expression)			EPHA3		C116926
CTD	decreases(expression)			EPHB6		C116926
CTD	decreases(expression)			ETV5		C116926
CTD	decreases(expression)			FABP4		C116926
CTD	affects(expression)			FAF1		C116926
CTD	decreases(expression)			FAIM2		C116926
CTD	increases(expression)			FLNB		C116926
CTD	decreases(expression)			FOXD1		C116926
CTD	affects(expression)			FRZB		C116926
CTD	decreases(expression)			GATA3		C116926
CTD	decreases(expression)			HGF		C116926
CTD	decreases(expression)			HPGD		C116926
CTD	affects(expression)			IL1A		C116926
CTD	decreases(reaction)			IL1B		C116926
CTD	increases(activity)			IL1B		C116926
CTD	decreases(reaction)			IL1B		C116926
CTD	increases(activity)			IL1B		C116926
CTD	increases(expression)			IL1RN		C116926
CTD	increases(expression)			IL6		C116926
CTD	decreases(expression)			INSM1		C116926
CTD	affects(expression)			ITGBL1		C116926
CTD	affects(expression)			KLF12		C116926
CTD	decreases(expression)			LIFR		C116926
CTD	increases(expression)			LMX1A		C116926
CTD	increases(expression)			MAL		C116926
CTD	decreases(expression)			MAPRE2		C116926
CTD	decreases(expression)			MBTD1		C116926
CTD	affects(expression)			MEF2C		C116926
CTD	decreases(expression)			MEOX2		C116926
CTD	affects(expression)			MLLT4		C116926
CTD	increases(expression)			MMP1		C116926
CTD	increases(expression)			MMP3		C116926
CTD	decreases(expression)			MTA2		C116926
CTD	decreases(expression)			NAALADL2		C116926
CTD	decreases(expression)			NFASC		C116926
CTD	affects(expression)			NOS1		C116926
CTD	increases(expression)			NPAS3		C116926
CTD	decreases(expression)			NPR2		C116926
CTD	affects(expression)			NQO1		C116926
CTD	decreases(expression)			PI4KA		C116926
CTD	affects(expression)			PLA2G2A		C116926
CTD	increases(expression)			PLAT		C116926
CTD	increases(expression)			PML		C116926
CTD	affects(expression)			POSTN		C116926
CTD	affects(expression)			PRRX1		C116926
CTD	decreases(expression)			PTGER3		C116926
CTD	decreases(expression)			PTGIS		C116926
CTD	decreases(activity)			PTGS1		C116926
CTD	decreases(expression)			PTGS1		C116926
CTD	increases(response to substance)			PTGS2		C116926
CTD	decreases(reaction)			PTGS2		C116926
CTD	increases(activity)			PTGS2		C116926
CTD	decreases(activity)			PTGS2		C116926
CTD	decreases(abundance)			PTGS2		C116926
CTD	decreases(activity)			PTGS2		C116926
CTD	increases(expression)			PTGS2		C116926
CTD	affects(expression)			RASA1		C116926
CTD	increases(expression)			RNF144B		C116926
CTD	decreases(expression)			RORC		C116926
CTD	increases(expression)			SCD		C116926
CTD	increases(expression)			SERPINA3		C116926
CTD	decreases(expression)			SH2D1A		C116926
CTD	increases(expression)			SOCS3		C116926
CTD	increases(expression)			SOD2		C116926
CTD	increases(expression)			STAT3		C116926
CTD	increases(expression)			TAC1		C116926
CTD	increases(expression)			TEAD4		C116926
CTD	affects(expression)			TFRC		C116926
CTD	decreases(expression)			TIMP3		C116926
CTD	increases(expression)			TMPRSS4		C116926
CTD	increases(expression)			TNC		C116926
CTD	decreases(expression)			TNF		C116926
CTD	affects(expression)			TRIM17		C116926
CTD	decreases(expression)			TSPAN2		C116926
CTD	decreases(expression)			VCAN		C116926
CTD	decreases(expression)			ZNF559		C116926
PubChem	Potency	uM	2.818	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		MBD2	-	GI(Protien) :
PubChem	None	uM		MBD2	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
ChEMBL	Potency	nM	2818.400	ALDH1A1	-	Target : CHEMBL3577

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