Tan Lab | DSigDB

Gene Set: D4 : CTD - esculetin

Collection

D4 : CTD

Chemical Name

esculetin ( From PubChem : ESCULETIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
178.142 g/mol	2	4	1.2042	True

Structure

InChI

InChI=1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H

InChIKey

ILEDWLMCKZNDJK-UHFFFAOYSA-N

Links

Gene (41 / 75)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(localization)			BAX		C007628
CTD	affects(cotreatment)			BAX		C007628
CTD	increases(expression)			BAX		C007628
CTD	affects(cotreatment)			BCL2L1		C007628
CTD	decreases(expression)			BCL2L1		C007628
CTD	affects(cotreatment)			BID		C007628
CTD	increases(cleavage)			BID		C007628
CTD	affects(cotreatment)			CASP3		C007628
CTD	increases(activity)			CASP3		C007628
CTD	increases(cleavage)			CASP3		C007628
CTD	affects(cotreatment)			CASP8		C007628
CTD	increases(activity)			CASP8		C007628
CTD	increases(cleavage)			CASP8		C007628
CTD	increases(methylation)			COMT		C007628
CTD	affects(cotreatment)			CYCS		C007628
CTD	affects(localization)			CYCS		C007628
CTD	affects(cotreatment)			CYCS		C007628
CTD	affects(localization)			CYCS		C007628
CTD	affects(cotreatment)			FAS		C007628
CTD	increases(expression)			FAS		C007628
CTD	affects(cotreatment)			FASLG		C007628
CTD	increases(expression)			FASLG		C007628
CTD	affects(cotreatment)			MAPK1		C007628
CTD	decreases(expression)			MAPK1		C007628
CTD	decreases(activity)			MAPK1		C007628
CTD	decreases(phosphorylation)			MAPK1		C007628
CTD	affects(cotreatment)			MAPK14		C007628
CTD	decreases(expression)			MAPK14		C007628
CTD	decreases(activity)			MAPK14		C007628
CTD	decreases(phosphorylation)			MAPK14		C007628
CTD	affects(cotreatment)			MAPK3		C007628
CTD	decreases(expression)			MAPK3		C007628
CTD	decreases(activity)			MAPK3		C007628
CTD	decreases(phosphorylation)			MAPK3		C007628
CTD	affects(cotreatment)			MAPK8		C007628
CTD	increases(expression)			MAPK8		C007628
CTD	increases(phosphorylation)			MAPK8		C007628
CTD	affects(cotreatment)			MAPK9		C007628
CTD	increases(expression)			MAPK9		C007628
CTD	increases(localization)			NFE2L2		C007628
CTD	increases(activity)			NQO1		C007628
CTD	increases(expression)			NQO1		C007628
CTD	increases(expression)			TNFRSF10A		C007628
CTD	increases(degradation)			TP53		C007628
CTD	increases(metabolic processing)			UGT2B15		C007628
PubChem	None	uM		ALPI	-	GI(Protien) :
PubChem	IC50	uM		CBFB	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	AC50_uM	uM	9.720	ERAP1	-	GI(Protien) :
PubChem	AbsAC200_uM	uM	3.270	ERAP2	-	GI(Protien) :
PubChem	Potency	uM	6.310	GAA	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	None	uM		MBD2	-	GI(Protien) :
PubChem	None	uM		NOD2	-	GI(Protien) :
PubChem	None	uM		NOD2	-	GI(Protien) :
PubChem	Potency	uM	2.668	POLK	-	GI(Protien) :
PubChem	Potency	uM	3.548	POLK	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		RGS8	-	GI(Protien) :
PubChem	None	uM		RIPK2	-	GI(Protien) :
PubChem	None	uM		RIPK2	-	GI(Protien) :
PubChem	IC50	uM		RUNX1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
ChEMBL	Potency	nM	6309.600	GAA	-	Target : CHEMBL2608
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159

Download gene sets

gmt, text, Detailed text