Tan Lab | DSigDB

Gene Set: D4 : CTD - domiphen

Collection

D4 : CTD

Chemical Name

domiphen ( From PubChem : DOMIPHEN BROMIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
414.463 g/mol	0	1	3.0667	True

Structure

InChI

InChI=1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1

InChIKey

Links

Gene (9 / 18)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			KCNA3		C007556
CTD	decreases(import)			KCNA3		C007556
CTD	decreases(activity)			KCNH2		C007556
CTD	decreases(import)			KCNH2		C007556
PubChem	Potency	uM	14.125	ALDH1A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.849	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.558	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.331	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.132	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	12.589	ESR1	-	GI(Protien) :
PubChem	Potency	uM	4.467	GBA	-	GI(Protien) :
PubChem	Potency	uM	5.012	KCNH2		GI(Protien) :
PubChem	Potency	uM	5.012	KCNH2		GI(Protien) :
PubChem	Potency	uM	0.531	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.189	TDP1	-	GI(Protien) :
PubChem	Potency	uM	79.433	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	14125.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	4466.800	GBA	-	Target : CHEMBL2179

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