Tan Lab | DSigDB

Gene Set: D4 : CTD - ezetimibe

Collection

D4 : CTD

Chemical Name

ezetimibe ( From PubChem : EZETIMIBE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
409.425 g/mol	2	4	4.9533	True

Structure

InChI

InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

InChIKey

OLNTVTPDXPETLC-XPWALMASSA-N

Links

Gene (21 / 38)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ABCA1		C108606
CTD	decreases(reaction)			ABCB11		C108606
CTD	increases(transport)			ABCB11		C108606
CTD	decreases(activity)			ABCB11		C108606
CTD	affects(cotreatment)			APOA1		C108606
CTD	increases(expression)			APOA1		C108606
CTD	affects(cotreatment)			APOA1		C108606
CTD	increases(expression)			APOA1		C108606
CTD	increases(reaction)			APOA1		C108606
CTD	affects(cotreatment)			CRP		C108606
CTD	decreases(expression)			CRP		C108606
CTD	affects(cotreatment)			CRP		C108606
CTD	decreases(expression)			CRP		C108606
CTD	increases(reaction)			CRP		C108606
CTD	increases(activity)			HMGCR		C108606
CTD	affects(cotreatment)			HMGCR		C108606
CTD	increases(expression)			HMGCR		C108606
CTD	affects(cotreatment)			LDLR		C108606
CTD	increases(expression)			LDLR		C108606
CTD	decreases(expression)			NPC1L1		C108606
CTD	decreases(response to substance)			NPC1L1		C108606
CTD	decreases(expression)			NR1H2		C108606
CTD	affects(cotreatment)			PCSK9		C108606
CTD	increases(expression)			PCSK9		C108606
CTD	affects(cotreatment)			PLA2G7		C108606
CTD	decreases(activity)			PLA2G7		C108606
CTD	decreases(expression)			RARG		C108606
CTD	decreases(expression)			SCARB1		C108606
CTD	decreases(expression)			SREBF1		C108606
CTD	decreases(expression)			SREBF2		C108606
CTD	increases(glucuronidation)			UGT1A1		C108606
CTD	increases(glucuronidation)			UGT1A3		C108606
CTD	increases(glucuronidation)			UGT2B15		C108606
CTD	increases(glucuronidation)			UGT2B7		C108606
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	Potency	uM	5.012	NPSR1	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
ChEMBL	Potency	nM	5011.900	NPSR1	-	Target : CHEMBL5162

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