Tan Lab | DSigDB

Gene Set: D4 : CTD - dutasteride

Collection

D4 : CTD

Chemical Name

dutasteride ( From PubChem : DUTASTERIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
528.53 g/mol	2	4	6.9779	False(2/4)

Structure

InChI

InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChIKey

JWJOTENAMICLJG-QWBYCMEYSA-N

Links

Gene (20 / 26)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ADI1		C108373
CTD	increases(expression)			AKR1C1		C108373
CTD	increases(expression)			AKR1C2		C108373
CTD	increases(expression)			AKR1C3		C108373
CTD	increases(expression)			AR		C108373
CTD	increases(expression)			CALR		C108373
CTD	increases(reaction)			CALR		C108373
CTD	decreases(expression)			CALR		C108373
CTD	increases(expression)			CCND1		C108373
CTD	increases(expression)			CYP11B2		C108373
CTD	decreases(expression)			DHCR24		C108373
CTD	increases(expression)			EAF2		C108373
CTD	increases(reaction)			EAF2		C108373
CTD	decreases(expression)			EAF2		C108373
CTD	increases(expression)			ERBB2		C108373
CTD	increases(expression)			HSD17B1		C108373
CTD	increases(expression)			HSD17B3		C108373
CTD	decreases(expression)			KLK2		C108373
CTD	decreases(expression)			KLK3		C108373
CTD	increases(expression)			SOS1		C108373
CTD	decreases(activity)			SRD5A1		C108373
CTD	decreases(expression)			SRD5A1		C108373
CTD	decreases(expression)			SRD5A2		C108373
CTD	increases(expression)			VCAM1		C108373
PubChem	Potency-Replicate_1	uM	21.132	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	16.930	NR3C1	-	GI(Protien) :

Download gene sets

gmt, text, Detailed text