Tan Lab | DSigDB

Gene Set: D4 : CTD - AG 494

Collection

D4 : CTD

Chemical Name

AG 494 ( From PubChem : TYRPHOSTIN B48 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
280.278 g/mol	3	5	2.71648	True

Structure

InChI

InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+

InChIKey

HKHOVJYOELRGMV-XYOKQWHBSA-N

Links

Gene (30 / 57)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(localization)			AHR		C107502
CTD	decreases(reaction)			AHR		C107502
CTD	decreases(reaction)			CYP1A1		C107502
CTD	increases(expression)			CYP1A1		C107502
PubChem	Potency	uM	3.162	ALOX15	-	GI(Protien) :
PubChem	None	uM		ALPI	-	GI(Protien) :
PubChem	Potency	uM	12.589	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	12.589	CBX1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	6.310	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	7.080	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	18.888	FEN1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	0.631	GLS	-	GI(Protien) :
PubChem	Potency	uM	12.589	GMNN	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	None	uM		IDE	-	GI(Protien) :
PubChem	None	uM		IDE	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPT	-	GI(Protien) :
PubChem	Potency	uM	10.621	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	12.589	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	25.119	PKM	-	GI(Protien) :
PubChem	Potency	uM	12.589	POLH	-	GI(Protien) :
PubChem	Potency	uM	56.234	POLI	-	GI(Protien) :
PubChem	IC50	uM	1.300	PSMD14	-	GI(Protien) :
PubChem	None	uM		PSMD14	-	GI(Protien) :
PubChem	None	uM		PSMD14	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	22.387	SMN2	-	GI(Protien) :
PubChem	Potency	uM	10.000	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	3162.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	12589.300	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	12589.300	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	501.190	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	6309.600	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7079.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	18887.600	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	12589.300	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	10000.000	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	15848.900	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	10621.300	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	12589.300	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	25118.900	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	22387.200	SMN1; SMN2	-	Target : CHEMBL1293232

Download gene sets

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