Tan Lab | DSigDB

Gene Set: D4 : CTD - everolimus

Collection

D4 : CTD

Chemical Name

everolimus ( From PubChem : EVEROLIMUS )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
958.224 g/mol	3	15	6.1351	False(1/4)

Structure

InChI

InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12-,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40?,41?,43-,44+,45?,46-,48-,49+,53-/m1/s1

InChIKey

HKVAMNSJSFKALM-ABQYLSKHSA-N

Links

Gene (24 / 58)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB11		C107135
CTD	decreases(phosphorylation)			AKT1		C107135
CTD	increases(phosphorylation)			AKT1		C107135
CTD	decreases(expression)			BIRC5		C107135
CTD	increases(cleavage)			CASP3		C107135
CTD	decreases(expression)			CCNA2		C107135
CTD	decreases(expression)			CCND1		C107135
CTD	affects(cotreatment)			CCND1		C107135
CTD	decreases(expression)			CCND2		C107135
CTD	affects(cotreatment)			CCND2		C107135
CTD	decreases(expression)			CCND3		C107135
CTD	decreases(phosphorylation)			EIF4E		C107135
CTD	decreases(reaction)			EIF4E		C107135
CTD	increases(phosphorylation)			EIF4E		C107135
CTD	decreases(activity)			EIF4EBP1		C107135
CTD	decreases(reaction)			EIF4EBP1		C107135
CTD	increases(phosphorylation)			EIF4EBP1		C107135
CTD	decreases(phosphorylation)			EIF4EBP1		C107135
CTD	affects(cotreatment)			EIF4EBP1		C107135
CTD	decreases(reaction)			EIF4G1		C107135
CTD	increases(phosphorylation)			EIF4G1		C107135
CTD	increases(expression)			F3		C107135
CTD	increases(reaction)			F3		C107135
CTD	affects(activity)			MTOR		C107135
CTD	decreases(reaction)			MTOR		C107135
CTD	decreases(reaction)			MTOR		C107135
CTD	decreases(response to substance)			MTOR		C107135
CTD	decreases(activity)			MTOR		C107135
CTD	decreases(activity)			MTOR		C107135
CTD	affects(cotreatment)			MTOR		C107135
CTD	decreases(expression)			NOS3		C107135
CTD	decreases(reaction)			NOS3		C107135
CTD	affects(activity)			RB1		C107135
CTD	decreases(phosphorylation)			RB1		C107135
CTD	decreases(phosphorylation)			RB1		C107135
CTD	affects(cotreatment)			RB1		C107135
CTD	decreases(reaction)			RPS6		C107135
CTD	increases(phosphorylation)			RPS6		C107135
CTD	decreases(phosphorylation)			RPS6		C107135
CTD	affects(cotreatment)			RPS6		C107135
CTD	decreases(phosphorylation)			RPS6		C107135
CTD	decreases(reaction)			RPS6KB1		C107135
CTD	increases(phosphorylation)			RPS6KB1		C107135
CTD	decreases(reaction)			RPS6KB1		C107135
CTD	increases(phosphorylation)			RPS6KB1		C107135
CTD	decreases(expression)			SIRT1		C107135
CTD	decreases(reaction)			SIRT1		C107135
CTD	decreases(reaction)			TNF		C107135
CTD	increases(phosphorylation)			TNF		C107135
CTD	increases(expression)			TNF		C107135
CTD	increases(reaction)			TNF		C107135
PubChem	Potency-Replicate_1	uM	23.710	AR	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.004	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.005	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.562	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.027	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.042	TDP1	-	GI(Protien) :

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