Tan Lab | DSigDB

Gene Set: D4 : CTD - 6,7-dimethoxy-3-phenylquinoxaline

Collection

D4 : CTD

Chemical Name

6,7-dimethoxy-3-phenylquinoxaline ( From PubChem : TYRPHOSTIN AG 1296 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
266.295 g/mol	0	4	3.314	True

Structure

InChI

InChI=1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3

InChIKey

Links

Gene (9 / 22)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(phosphorylation)			AKT1		C106250
CTD	affects(cotreatment)			MAPK1		C106250
CTD	decreases(activity)			MAPK1		C106250
CTD	affects(cotreatment)			MAPK3		C106250
CTD	decreases(activity)			MAPK3		C106250
CTD	decreases(reaction)			PDGFB		C407689
CTD	increases(expression)			PDGFB		C407689
CTD	increases(secretion)			PDGFB		C407689
CTD	decreases(reaction)			PDGFRB		C407689
CTD	increases(expression)			PDGFRB		C407689
CTD	decreases(reaction)			PDGFRB		C106250
CTD	increases(activity)			PDGFRB		C106250
CTD	increases(phosphorylation)			PDGFRB		C106250
PubChem	irf1 Inhibition [HEL cells] (IC50)	uM	0.690	JAK2	-	GI(Protien) :
PubChem	Potency	uM	15.849	SMN2	-	GI(Protien) :
PubChem	Potency	uM	28.184	SMN2	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.119	TDP1	-	GI(Protien) :
PubChem	Potency	uM	35.481	TDP1	-	GI(Protien) :
ChEMBL	Activity	um	0.690	JAK2	-	Target : CHEMBL2971
ChEMBL	Potency	nM	28183.800	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	15848.900	SMN1; SMN2	-	Target : CHEMBL1293232

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