Tan Lab | DSigDB

Gene Set: D4 : CTD - alitretinoin

Collection

D4 : CTD

Chemical Name

alitretinoin ( From PubChem : ALITRETINOIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
300.435 g/mol	1	2	5.6026	False(3/4)

Structure

InChI

InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+

InChIKey

SHGAZHPCJJPHSC-ZVCIMWCZSA-N

Links

Gene (212 / 438)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ABCA1		C103303
CTD	increases(expression)			ABCA1		C103303
CTD	affects(cotreatment)			ABCA1		C103303
CTD	increases(expression)			ABCA1		C103303
CTD	decreases(reaction)			ABCA1		C103303
CTD	increases(expression)			ABCC6		C103303
CTD	increases(reaction)			ABCC6		C103303
CTD	increases(expression)			ABCG1		C103303
CTD	affects(cotreatment)			ABCG1		C103303
CTD	increases(expression)			ABCG1		C103303
CTD	affects(cotreatment)			ADIPOR1		C103303
CTD	decreases(expression)			ADIPOR1		C103303
CTD	decreases(expression)			AIP		C103303
CTD	decreases(phosphorylation)			AKT1		C103303
CTD	decreases(reaction)			APP		C103303
CTD	decreases(secretion)			APP		C103303
CTD	increases(expression)			BAX		C103303
CTD	increases(expression)			BAX		C103303
CTD	decreases(reaction)			BAX		C103303
CTD	increases(expression)			BAX		C103303
CTD	decreases(expression)			BCL2		C103303
CTD	decreases(expression)			BCL2		C103303
CTD	decreases(response to substance)			BCL2		C103303
CTD	increases(expression)			BCL2L11		C103303
CTD	decreases(reaction)			BCL2L11		C103303
CTD	increases(expression)			BGLAP		C103303
CTD	increases(reaction)			BGLAP		C103303
CTD	increases(secretion)			BGLAP		C103303
CTD	affects(binding)			BGLAP		C103303
CTD	decreases(expression)			BGLAP		C103303
CTD	affects(cotreatment)			BGLAP		C103303
CTD	affects(cotreatment)			CA2		C103303
CTD	increases(expression)			CA2		C103303
CTD	increases(expression)			CASP3		C103303
CTD	increases(expression)			CASP3		C103303
CTD	increases(activity)			CASP8		C103303
CTD	decreases(expression)			CBX3		C103303
CTD	affects(binding)			CCL2		C103303
CTD	affects(cotreatment)			CCL2		C103303
CTD	decreases(reaction)			CCL2		C103303
CTD	increases(reaction)			CCL2		C103303
CTD	decreases(expression)			CCND3		C103303
CTD	decreases(expression)			CCR2		C103303
CTD	decreases(reaction)			CCR2		C103303
CTD	increases(expression)			CCR3		C103303
CTD	decreases(expression)			CCR7		C103303
CTD	increases(expression)			CCR7		C103303
CTD	decreases(expression)			CD1A		C103303
CTD	decreases(reaction)			CD1A		C103303
CTD	affects(cotreatment)			CD1A		C103303
CTD	decreases(expression)			CD36		C103303
CTD	decreases(reaction)			CD36		C103303
CTD	affects(cotreatment)			CD36		C103303
CTD	increases(expression)			CD36		C103303
CTD	increases(expression)			CD38		C103303
CTD	increases(expression)			CD38		C103303
CTD	increases(reaction)			CD38		C103303
CTD	decreases(reaction)			CD38		C103303
CTD	decreases(expression)			CD80		C103303
CTD	decreases(reaction)			CD80		C103303
CTD	affects(cotreatment)			CD80		C103303
CTD	increases(expression)			CD83		C103303
CTD	decreases(reaction)			CD86		C103303
CTD	increases(expression)			CD86		C103303
CTD	affects(cotreatment)			CD86		C103303
CTD	affects(expression)			CDH1		C103303
CTD	decreases(expression)			CDKN1A		C103303
CTD	increases(expression)			CDKN1B		C103303
CTD	decreases(reaction)			CDKN1B		C103303
CTD	decreases(expression)			CDKN1C		C103303
CTD	affects(cotreatment)			CETP		C103303
CTD	increases(expression)			CETP		C103303
CTD	increases(expression)			CGB		C103303
CTD	increases(expression)			CIITA		C103303
CTD	decreases(expression)			COL17A1		C103303
CTD	increases(expression)			COL1A1		C103303
CTD	increases(expression)			COL4A2		C103303
CTD	decreases(expression)			COL6A1		C103303
CTD	increases(expression)			COL8A2		C103303
CTD	decreases(response to substance)			CRABP1		C103303
CTD	increases(expression)			CRABP2		C103303
CTD	increases(phosphorylation)			CREB1		C103303
CTD	decreases(expression)			CXCL1		C103303
CTD	affects(binding)			CYP19A1		C103303
CTD	increases(activity)			CYP19A1		C103303
CTD	increases(expression)			CYP19A1		C103303
CTD	affects(cotreatment)			CYP19A1		C103303
CTD	decreases(reaction)			CYP19A1		C103303
CTD	increases(expression)			CYP19A1		C103303
CTD	increases(reaction)			CYP19A1		C103303
CTD	increases(expression)			CYP26A1		C103303
CTD	decreases(expression)			CYP27A1		C103303
CTD	increases(expression)			CYP27A1		C103303
CTD	increases(reaction)			CYP27A1		C103303
CTD	decreases(reaction)			CYP27A1		C103303
CTD	affects(binding)			CYP3A4		C103303
CTD	increases(reaction)			CYP3A4		C103303
CTD	affects(binding)			CYP3A4		C103303
CTD	increases(expression)			CYP3A4		C103303
CTD	increases(reaction)			CYP3A4		C103303
CTD	increases(activity)			CYP3A4		C103303
CTD	decreases(expression)			CYP3A7		C103303
CTD	increases(expression)			DHRS9		C103303
CTD	increases(activity)			DIO3		C103303
CTD	decreases(expression)			DSC1		C103303
CTD	increases(expression)			DUSP10		C103303
CTD	decreases(expression)			DUSP11		C103303
CTD	decreases(expression)			EGFR		C103303
CTD	decreases(expression)			EIF4EBP2		C103303
CTD	increases(expression)			EMP1		C103303
CTD	decreases(reaction)			ESR1		C103303
CTD	increases(expression)			ESR1		C103303
CTD	decreases(reaction)			ESR2		C103303
CTD	increases(expression)			ESR2		C103303
CTD	decreases(expression)			FABP5		C103303
CTD	increases(expression)			FAM3C		C103303
CTD	decreases(expression)			FAS		C103303
CTD	increases(expression)			FAS		C103303
CTD	decreases(expression)			FASN		C103303
CTD	decreases(expression)			FASTK		C103303
CTD	decreases(expression)			FGF1		C103303
CTD	decreases(expression)			FLG		C103303
CTD	decreases(expression)			FN1		C103303
CTD	increases(expression)			FOXA1		C103303
CTD	increases(expression)			G6PD		C103303
CTD	increases(expression)			GATA6		C103303
CTD	decreases(expression)			GBA		C103303
CTD	increases(expression)			GDF15		C103303
CTD	decreases(expression)			GDF2		C103303
CTD	increases(expression)			GLUL		C103303
CTD	increases(expression)			GPX2		C103303
CTD	decreases(expression)			GRB7		C103303
CTD	decreases(expression)			GSTM1		C103303
CTD	increases(expression)			HBEGF		C103303
CTD	increases(expression)			HGF		C103303
CTD	increases(secretion)			HGF		C103303
CTD	affects(binding)			HIST3H3		C103303
CTD	affects(cotreatment)			HIST3H3		C103303
CTD	increases(reaction)			HIST3H3		C103303
CTD	increases(acetylation)			HIST3H3		C103303
CTD	affects(binding)			HIST4H4		C103303
CTD	affects(cotreatment)			HIST4H4		C103303
CTD	increases(reaction)			HIST4H4		C103303
CTD	increases(methylation)			HIST4H4		C103303
CTD	increases(acetylation)			HIST4H4		C103303
CTD	decreases(reaction)			HIST4H4		C103303
CTD	decreases(expression)			HSD11B1		C103303
CTD	increases(activity)			HSD17B1		C103303
CTD	increases(expression)			HSD17B1		C103303
CTD	affects(binding)			IFNG		C103303
CTD	affects(cotreatment)			IFNG		C103303
CTD	decreases(reaction)			IFNG		C103303
CTD	increases(reaction)			IFNG		C103303
CTD	increases(expression)			IFNG		C103303
CTD	increases(localization)			IFNG		C103303
CTD	increases(phosphorylation)			IFNG		C103303
CTD	decreases(expression)			IFNG		C103303
CTD	increases(expression)			IFNGR1		C103303
CTD	decreases(expression)			IGF1		C103303
CTD	increases(expression)			IGF1		C103303
CTD	affects(binding)			IGFBP3		C103303
CTD	increases(expression)			IGFBP3		C103303
CTD	increases(expression)			IGFBP3		C103303
CTD	decreases(expression)			IL10RA		C103303
CTD	affects(binding)			IL12A		C103303
CTD	decreases(reaction)			IL12A		C103303
CTD	increases(secretion)			IL12A		C103303
CTD	affects(binding)			IL12A		C103303
CTD	decreases(expression)			IL12A		C103303
CTD	affects(binding)			IL12B		C103303
CTD	decreases(reaction)			IL12B		C103303
CTD	increases(secretion)			IL12B		C103303
CTD	affects(binding)			IL12B		C103303
CTD	decreases(expression)			IL12B		C103303
CTD	increases(expression)			IL13		C103303
CTD	increases(expression)			IL1B		C103303
CTD	increases(reaction)			IL2		C103303
CTD	increases(secretion)			IL2		C103303
CTD	decreases(expression)			IL2		C103303
CTD	decreases(expression)			IL24		C103303
CTD	increases(expression)			IL4		C103303
CTD	increases(expression)			IL5		C103303
CTD	increases(expression)			IRF1		C103303
CTD	increases(expression)			IRF1		C103303
CTD	increases(expression)			IRF1		C103303
CTD	increases(expression)			ITGA4		C103303
CTD	increases(expression)			ITGAM		C103303
CTD	increases(reaction)			ITGAM		C103303
CTD	increases(expression)			ITGAX		C103303
CTD	increases(reaction)			ITGAX		C103303
CTD	increases(expression)			ITGB2		C103303
CTD	increases(reaction)			ITGB2		C103303
CTD	increases(expression)			IVL		C103303
CTD	affects(cotreatment)			JUN		C103303
CTD	increases(expression)			JUN		C103303
CTD	increases(expression)			KLK10		C103303
CTD	decreases(expression)			KRT1		C103303
CTD	decreases(expression)			KRT10		C103303
CTD	decreases(expression)			KRT14		C103303
CTD	increases(expression)			KRT15		C103303
CTD	decreases(expression)			KRT17		C103303
CTD	increases(expression)			KRT18		C103303
CTD	increases(expression)			KRT19		C103303
CTD	increases(expression)			KRT19		C103303
CTD	decreases(expression)			KRT5		C103303
CTD	decreases(expression)			KRT6A		C103303
CTD	increases(expression)			KRT7		C103303
CTD	increases(expression)			KRT7		C103303
CTD	decreases(expression)			KRT75		C103303
CTD	increases(expression)			KRT8		C103303
CTD	decreases(expression)			LAMA2		C103303
CTD	decreases(expression)			LAMA3		C103303
CTD	increases(expression)			LAMC3		C103303
CTD	increases(expression)			LCN2		C103303
CTD	affects(cotreatment)			LPL		C103303
CTD	increases(expression)			LPL		C103303
CTD	increases(expression)			MAP2		C103303
CTD	increases(expression)			MEIS1		C103303
CTD	increases(expression)			MEIS2		C103303
CTD	increases(expression)			MEOX1		C103303
CTD	increases(phosphorylation)			MET		C103303
CTD	decreases(expression)			MFAP2		C103303
CTD	decreases(expression)			MMP10		C103303
CTD	increases(expression)			MUC5AC		C103303
CTD	affects(binding)			NCOA1		C103303
CTD	affects(cotreatment)			NCOA1		C103303
CTD	increases(reaction)			NCOA1		C103303
CTD	affects(cotreatment)			NCOA1		C103303
CTD	increases(activity)			NCOA1		C103303
CTD	increases(expression)			NEDD9		C103303
CTD	increases(expression)			NEFH		C103303
CTD	decreases(expression)			NEFL		C103303
CTD	increases(expression)			NKX3-1		C103303
CTD	affects(cotreatment)			NR1H2		C103303
CTD	affects(localization)			NR1H2		C103303
CTD	affects(cotreatment)			NR1H3		C103303
CTD	affects(localization)			NR1H3		C103303
CTD	decreases(reaction)			NR1H3		C103303
CTD	increases(expression)			NR1H3		C103303
CTD	affects(binding)			NR1I2		C103303
CTD	increases(expression)			NR1I2		C103303
CTD	increases(reaction)			NR1I2		C103303
CTD	affects(binding)			NR1I3		C103303
CTD	affects(cotreatment)			NR1I3		C103303
CTD	increases(reaction)			NR1I3		C103303
CTD	affects(binding)			NR1I3		C103303
CTD	increases(reaction)			NR1I3		C103303
CTD	affects(cotreatment)			NR5A2		C103303
CTD	decreases(reaction)			NR5A2		C103303
CTD	increases(expression)			NR5A2		C103303
CTD	increases(reaction)			NR5A2		C103303
CTD	decreases(expression)			NR5A2		C103303
CTD	increases(expression)			NRL		C103303
CTD	decreases(expression)			ODC1		C103303
CTD	increases(expression)			OLR1		C103303
CTD	increases(expression)			PADI4		C103303
CTD	increases(reaction)			PADI4		C103303
CTD	increases(cleavage)			PARP1		C103303
CTD	increases(expression)			PCSK2		C103303
CTD	increases(expression)			PIR		C103303
CTD	increases(expression)			PLAT		C103303
CTD	affects(cotreatment)			PPARA		C103303
CTD	decreases(expression)			PPARA		C103303
CTD	increases(activity)			PPARG		C103303
CTD	increases(reaction)			PPARG		C103303
CTD	increases(expression)			PPARGC1A		C103303
CTD	affects(binding)			PRAME		C103303
CTD	increases(reaction)			PRAME		C103303
CTD	affects(cotreatment)			PSG5		C103303
CTD	increases(expression)			PSG5		C103303
CTD	affects(binding)			PSG5		C103303
CTD	increases(activity)			PSG5		C103303
CTD	decreases(expression)			PTGS1		C103303
CTD	decreases(expression)			PTGS2		C103303
CTD	decreases(expression)			PTHLH		C103303
CTD	increases(reaction)			PTHLH		C103303
CTD	decreases(expression)			RAB27A		C103303
CTD	decreases(response to substance)			RAB27A		C103303
CTD	affects(binding)			RARA		C103303
CTD	increases(activity)			RARA		C103303
CTD	affects(binding)			RARA		C103303
CTD	increases(reaction)			RARA		C103303
CTD	decreases(expression)			RARA		C103303
CTD	increases(expression)			RARA		C103303
CTD	increases(expression)			RARA		C103303
CTD	increases(reaction)			RARA		C103303
CTD	affects(binding)			RARB		C103303
CTD	increases(activity)			RARB		C103303
CTD	affects(binding)			RARB		C103303
CTD	increases(expression)			RARB		C103303
CTD	increases(expression)			RARB		C103303
CTD	affects(binding)			RARG		C103303
CTD	increases(activity)			RARG		C103303
CTD	decreases(expression)			RARG		C103303
CTD	increases(expression)			RARRES1		C103303
CTD	increases(expression)			RARRES3		C103303
CTD	decreases(phosphorylation)			RB1		C103303
CTD	decreases(expression)			RHOA		C103303
CTD	decreases(expression)			RHOB		C103303
CTD	decreases(expression)			RNF5		C103303
CTD	affects(binding)			RXRA		C103303
CTD	affects(cotreatment)			RXRA		C103303
CTD	increases(reaction)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	increases(reaction)			RXRA		C103303
CTD	affects(localization)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	increases(activity)			RXRA		C103303
CTD	affects(activity)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	increases(activity)			RXRA		C103303
CTD	increases(activity)			RXRA		C103303
CTD	increases(expression)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	affects(cotreatment)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	affects(cotreatment)			RXRA		C103303
CTD	increases(stability)			RXRA		C103303
CTD	affects(cotreatment)			RXRA		C103303
CTD	increases(expression)			RXRA		C103303
CTD	decreases(reaction)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	increases(expression)			RXRA		C103303
CTD	increases(reaction)			RXRA		C103303
CTD	decreases(expression)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	increases(activity)			RXRA		C103303
CTD	increases(degradation)			RXRA		C103303
CTD	increases(expression)			RXRA		C103303
CTD	increases(ubiquitination)			RXRA		C103303
CTD	decreases(reaction)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	decreases(reaction)			RXRA		C103303
CTD	affects(cotreatment)			RXRA		C103303
CTD	decreases(expression)			RXRA		C103303
CTD	affects(binding)			RXRA		C103303
CTD	affects(activity)			RXRB		C103303
CTD	affects(binding)			RXRB		C103303
CTD	affects(binding)			RXRB		C103303
CTD	affects(cotreatment)			RXRB		C103303
CTD	increases(activity)			RXRB		C103303
CTD	affects(binding)			RXRB		C103303
CTD	increases(reaction)			RXRB		C103303
CTD	increases(activity)			RXRB		C103303
CTD	increases(degradation)			RXRB		C103303
CTD	affects(activity)			RXRG		C103303
CTD	affects(binding)			RXRG		C103303
CTD	decreases(expression)			RXRG		C103303
CTD	decreases(expression)			S100A1		C103303
CTD	increases(expression)			S100A7		C103303
CTD	decreases(expression)			S100A8		C103303
CTD	increases(expression)			S100A9		C103303
CTD	increases(expression)			SCARB1		C103303
CTD	decreases(expression)			SEMA6B		C103303
CTD	increases(reaction)			SEMA6B		C103303
CTD	increases(expression)			SERPINA3		C103303
CTD	decreases(expression)			SERPINB2		C103303
CTD	decreases(expression)			SERPINB8		C103303
CTD	decreases(expression)			SERPINB9		C103303
CTD	decreases(reaction)			SERPINE1		C103303
CTD	increases(expression)			SERPINE1		C103303
CTD	decreases(expression)			SLC16A1		C103303
CTD	increases(expression)			SLC5A5		C103303
CTD	decreases(expression)			SOCS1		C103303
CTD	increases(expression)			SOCS2		C103303
CTD	decreases(expression)			SPP1		C103303
CTD	decreases(expression)			SPRR1B		C103303
CTD	affects(binding)			STAT1		C103303
CTD	affects(cotreatment)			STAT1		C103303
CTD	decreases(reaction)			STAT1		C103303
CTD	increases(reaction)			STAT1		C103303
CTD	increases(expression)			STAT1		C103303
CTD	increases(localization)			STAT1		C103303
CTD	increases(phosphorylation)			STAT1		C103303
CTD	increases(activity)			STAT1		C103303
CTD	increases(phosphorylation)			STAT1		C103303
CTD	increases(activity)			STS		C103303
CTD	decreases(expression)			SULT2A1		C103303
CTD	increases(expression)			TACSTD2		C103303
CTD	decreases(reaction)			TGFB1		C103303
CTD	increases(expression)			TGFB1		C103303
CTD	decreases(activity)			TGFB1		C103303
CTD	increases(expression)			TGFB1I1		C103303
CTD	increases(expression)			TGIF1		C103303
CTD	decreases(expression)			TGM1		C103303
CTD	affects(binding)			TGM2		C103303
CTD	affects(cotreatment)			TGM2		C103303
CTD	increases(reaction)			TGM2		C103303
CTD	increases(activity)			TGM2		C103303
CTD	increases(expression)			TGM2		C103303
CTD	increases(expression)			TGM2		C103303
CTD	increases(expression)			TGM2		C103303
CTD	decreases(reaction)			TGM2		C103303
CTD	decreases(expression)			THBS1		C103303
CTD	decreases(expression)			TNF		C103303
CTD	increases(expression)			TNFRSF10A		C103303
CTD	increases(expression)			TNFRSF10B		C103303
CTD	increases(expression)			TNFSF10		C103303
CTD	affects(cotreatment)			UGDH		C103303
CTD	decreases(expression)			UGDH		C103303
CTD	decreases(expression)			UVRAG		C103303
CTD	affects(activity)			VDR		C103303
CTD	affects(binding)			VDR		C103303
CTD	affects(cotreatment)			VDR		C103303
CTD	increases(stability)			VDR		C103303
CTD	affects(binding)			VDR		C103303
CTD	increases(reaction)			VDR		C103303
CTD	increases(degradation)			VDR		C103303
CTD	increases(expression)			VEGFA		C103303
CTD	decreases(expression)			VEGFC		C103303
CTD	decreases(reaction)			VIPR1		C103303
CTD	increases(expression)			VIPR1		C103303
CTD	decreases(expression)			WNT5B		C103303
PubChem	Potency	uM	22.387	EHMT2	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.179	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.243	ESR1	-	GI(Protien) :
PubChem	None	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		NR1H2	-	GI(Protien) :
PubChem	None	uM		NR1I3	-	GI(Protien) :
PubChem	None	uM		NR2C2	-	GI(Protien) :
PubChem	None	uM		NR2F6	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		NR4A3	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR6A1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.210	PPARG	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RARB	-	GI(Protien) :
PubChem	None	uM		RARG	-	GI(Protien) :
PubChem	None	uM		RXRA	-	GI(Protien) :
PubChem	None	uM		RXRA	-	GI(Protien) :
PubChem	None	uM		RXRA	-	GI(Protien) :
PubChem	None	uM		RXRG	-	GI(Protien) :
PubChem	Potency	uM	25.929	TDP1	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
PubChem	Potency	uM	56.234	VDR	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :

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