Tan Lab | DSigDB

Gene Set: D4 : CTD - 4,5,6,7-tetrabromobenzotriazole

Collection

D4 : CTD

Chemical Name

4,5,6,7-tetrabromobenzotriazole ( From PubChem : 4,5,6,7-TETRABROMOBENZOTRIAZOLE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
434.708 g/mol	1	2	4.0079	True

Structure

InChI

InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)

InChIKey

OMZYUVOATZSGJY-UHFFFAOYSA-N

Links

Gene (23 / 49)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			BAX		C405354
CTD	increases(expression)			BAX		C405354
CTD	affects(cotreatment)			BCL2		C405354
CTD	decreases(expression)			BCL2		C405354
CTD	affects(cotreatment)			BCL2L1		C405354
CTD	decreases(expression)			BCL2L1		C405354
CTD	affects(cotreatment)			CASP3		C405354
CTD	increases(activity)			CASP3		C405354
CTD	increases(cleavage)			CASP3		C405354
CTD	affects(cotreatment)			CASP8		C405354
CTD	increases(activity)			CASP8		C405354
CTD	affects(cotreatment)			CASP9		C405354
CTD	increases(activity)			CASP9		C405354
CTD	increases(cleavage)			CASP9		C405354
CTD	affects(binding)			CSNK2A1		C405354
CTD	affects(cotreatment)			CSNK2A1		C405354
CTD	decreases(reaction)			CSNK2A1		C405354
CTD	increases(reaction)			CSNK2A1		C405354
CTD	decreases(activity)			IKZF1		C405354
CTD	decreases(reaction)			IKZF1		C405354
CTD	decreases(phosphorylation)			RNF7		C103118
CTD	affects(binding)			SLC39A7		C405354
CTD	affects(cotreatment)			SLC39A7		C405354
CTD	decreases(reaction)			SLC39A7		C405354
CTD	increases(reaction)			SLC39A7		C405354
CTD	affects(cotreatment)			TNFSF10		C405354
CTD	decreases(expression)			TNFSF10		C405354
CTD	increases(activity)			TNFSF10		C405354
CTD	increases(cleavage)			TNFSF10		C405354
CTD	increases(expression)			TNFSF10		C405354
PubChem	Potency	uM	25.919	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	28.184	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	None	uM		GEM	-	GI(Protien) :
PubChem	None	uM		ITPKC	-	GI(Protien) :
PubChem	Potency	uM	28.184	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	18.356	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	5.012	NFKB1	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	56.234	USP1	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	25918.500	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	2511.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	28183.800	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	18356.400	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	5011.900	NFKB1	-	Target : CHEMBL3251

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