Tan Lab | DSigDB

Gene Set: D4 : CTD - tyrphostin AG 1478

Collection

D4 : CTD

Chemical Name

tyrphostin AG 1478 ( From PubChem : 170449-18-0 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
352.215 g/mol	2	4	4.919	True

Structure

InChI

InChI=1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

InChIKey

WDJDYIUSDDVWKB-UHFFFAOYSA-N

Links

Gene (70 / 376)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ADRB1		C101044
CTD	decreases(reaction)			ADRB1		C101044
CTD	increases(phosphorylation)			ADRB1		C101044
CTD	increases(reaction)			ADRB1		C101044
CTD	decreases(reaction)			AKT1		C101044
CTD	increases(activity)			AKT1		C101044
CTD	increases(phosphorylation)			AKT1		C101044
CTD	decreases(reaction)			AKT1		C101044
CTD	increases(activity)			AKT1		C101044
CTD	increases(phosphorylation)			AKT1		C101044
CTD	decreases(reaction)			AKT1		C101044
CTD	increases(phosphorylation)			AKT1		C101044
CTD	affects(binding)			ALB		C101044
CTD	decreases(reaction)			ALB		C101044
CTD	increases(expression)			ALB		C101044
CTD	increases(phosphorylation)			ALB		C101044
CTD	affects(cotreatment)			ALOX5		C101044
CTD	decreases(reaction)			ALOX5		C101044
CTD	increases(expression)			ALOX5		C101044
CTD	decreases(reaction)			ANGPT1		C101044
CTD	increases(expression)			ANGPT1		C101044
CTD	decreases(reaction)			ANGPT2		C101044
CTD	increases(expression)			ANGPT2		C101044
CTD	decreases(expression)			AR		C101044
CTD	decreases(reaction)			AR		C101044
CTD	affects(cotreatment)			AREG		C101044
CTD	decreases(reaction)			AREG		C101044
CTD	increases(phosphorylation)			AREG		C101044
CTD	decreases(reaction)			ATF1		C101044
CTD	increases(phosphorylation)			ATF1		C101044
CTD	decreases(expression)			BMP4		C101044
CTD	decreases(reaction)			BMP4		C101044
CTD	decreases(reaction)			CAV1		C101044
CTD	increases(expression)			CAV1		C101044
CTD	decreases(expression)			CCNE1		C101044
CTD	decreases(reaction)			CDKN1A		C101044
CTD	increases(expression)			CDKN1A		C101044
CTD	decreases(reaction)			CDKN1A		C101044
CTD	increases(expression)			CDKN1A		C101044
CTD	decreases(reaction)			CREB1		C101044
CTD	increases(phosphorylation)			CREB1		C101044
CTD	decreases(reaction)			CSF2		C101044
CTD	increases(secretion)			CSF2		C101044
CTD	affects(binding)			CSF2		C101044
CTD	decreases(reaction)			CSF2		C101044
CTD	increases(expression)			CSF2		C101044
CTD	affects(localization)			CTNNB1		C101044
CTD	decreases(reaction)			CTNNB1		C101044
CTD	affects(reaction)			CXCL8		C101044
CTD	increases(secretion)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(secretion)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(expression)			CXCL8		C101044
CTD	increases(secretion)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(expression)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(secretion)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(secretion)			CXCL8		C101044
CTD	affects(binding)			CXCL8		C101044
CTD	decreases(reaction)			CXCL8		C101044
CTD	increases(expression)			CXCL8		C101044
CTD	increases(expression)			CYLD		C101044
CTD	decreases(reaction)			EDN1		C101044
CTD	increases(expression)			EDN1		C101044
CTD	decreases(expression)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	decreases(secretion)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	increases(abundance)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	increases(expression)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	increases(activity)			EGF		C101044
CTD	increases(phosphorylation)			EGF		C101044
CTD	increases(phosphorylation)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	increases(phosphorylation)			EGF		C101044
CTD	increases(secretion)			EGF		C101044
CTD	decreases(reaction)			EGF		C101044
CTD	increases(phosphorylation)			EGF		C101044
CTD	increases(reaction)			EGF		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	affects(cotreatment)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	increases(reaction)			EGFR		C101044
CTD	affects(cotreatment)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	affects(binding)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(reaction)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(activity)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(activity)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(chemical synthesis)			EGFR		C101044
CTD	increases(activity)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(chemical synthesis)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(reaction)			EGFR		C101044
CTD	increases(activity)			EGFR		C101044
CTD	increases(phosphorylation)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(response to substance)			EGFR		C101044
CTD	decreases(response to substance)			EGFR		C101044
CTD	decreases(response to substance)			EGFR		C101044
CTD	decreases(activity)			EGFR		C101044
CTD	decreases(response to substance)			EGFR		C101044
CTD	decreases(phosphorylation)			EGFR		C101044
CTD	decreases(reaction)			EGR1		C101044
CTD	increases(expression)			EGR1		C101044
CTD	decreases(expression)			F11R		C101044
CTD	decreases(reaction)			F11R		C101044
CTD	decreases(reaction)			FGF2		C101044
CTD	increases(expression)			FGF2		C101044
CTD	decreases(reaction)			FLT1		C101044
CTD	increases(secretion)			FLT1		C101044
CTD	decreases(reaction)			FOS		C101044
CTD	increases(expression)			FOS		C101044
CTD	decreases(reaction)			FOS		C101044
CTD	increases(expression)			FOS		C101044
CTD	decreases(reaction)			FOS		C101044
CTD	increases(expression)			FOS		C101044
CTD	decreases(activity)			FOXO3		C101044
CTD	decreases(reaction)			FOXO3		C101044
CTD	increases(phosphorylation)			FOXO3		C101044
CTD	decreases(activity)			FSHB		C101044
CTD	decreases(reaction)			FSHB		C101044
CTD	increases(chemical synthesis)			FSHB		C101044
CTD	decreases(response to substance)			FSHB		C101044
CTD	decreases(reaction)			GPER1		C101044
CTD	increases(expression)			GPER1		C101044
CTD	affects(binding)			GPER1		C101044
CTD	decreases(reaction)			HBEGF		C101044
CTD	increases(expression)			HBEGF		C101044
CTD	decreases(expression)			HES1		C101044
CTD	decreases(reaction)			HES1		C101044
CTD	decreases(reaction)			HMOX1		C101044
CTD	increases(expression)			HMOX1		C101044
CTD	affects(reaction)			IL6		C101044
CTD	increases(secretion)			IL6		C101044
CTD	decreases(reaction)			IL6		C101044
CTD	increases(expression)			IL6		C101044
CTD	decreases(reaction)			IL6		C101044
CTD	increases(secretion)			IL6		C101044
CTD	decreases(expression)			IVL		C101044
CTD	decreases(reaction)			IVL		C101044
CTD	increases(expression)			IVL		C101044
CTD	decreases(expression)			JAG1		C101044
CTD	decreases(reaction)			JAG1		C101044
CTD	decreases(activity)			JAK3		C101044
CTD	decreases(phosphorylation)			JAK3		C101044
CTD	decreases(reaction)			JUN		C101044
CTD	increases(phosphorylation)			JUN		C101044
CTD	decreases(expression)			KLK3		C101044
CTD	decreases(reaction)			KLK3		C101044
CTD	decreases(secretion)			KLK3		C101044
CTD	increases(expression)			KRT1		C101044
CTD	decreases(expression)			KRT10		C101044
CTD	decreases(reaction)			KRT10		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	affects(cotreatment)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	increases(reaction)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	affects(binding)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(activity)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(activity)			MAPK1		C101044
CTD	decreases(reaction)			MAPK1		C101044
CTD	increases(activity)			MAPK1		C101044
CTD	increases(phosphorylation)			MAPK1		C101044
CTD	decreases(activity)			MAPK1		C101044
CTD	decreases(phosphorylation)			MAPK1		C101044
CTD	decreases(phosphorylation)			MAPK1		C101044
CTD	decreases(reaction)			MAPK14		C101044
CTD	increases(phosphorylation)			MAPK14		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	affects(cotreatment)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	increases(reaction)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	affects(binding)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(activity)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(activity)			MAPK3		C101044
CTD	decreases(reaction)			MAPK3		C101044
CTD	increases(activity)			MAPK3		C101044
CTD	increases(phosphorylation)			MAPK3		C101044
CTD	decreases(activity)			MAPK3		C101044
CTD	decreases(phosphorylation)			MAPK3		C101044
CTD	decreases(phosphorylation)			MAPK3		C101044
CTD	decreases(reaction)			MAPK8		C101044
CTD	increases(phosphorylation)			MAPK8		C101044
CTD	decreases(reaction)			MMP1		C101044
CTD	increases(secretion)			MMP1		C101044
CTD	increases(expression)			MMP1		C101044
CTD	decreases(reaction)			MMP14		C101044
CTD	increases(expression)			MMP14		C101044
CTD	decreases(reaction)			MMP2		C101044
CTD	increases(expression)			MMP2		C101044
CTD	decreases(reaction)			MMP7		C101044
CTD	increases(expression)			MMP7		C101044
CTD	decreases(reaction)			MMP9		C101044
CTD	increases(expression)			MMP9		C101044
CTD	decreases(reaction)			MMP9		C101044
CTD	increases(activity)			MMP9		C101044
CTD	increases(secretion)			MMP9		C101044
CTD	decreases(reaction)			MMP9		C101044
CTD	increases(secretion)			MMP9		C101044
CTD	decreases(reaction)			MUC5AC		C101044
CTD	increases(expression)			MUC5AC		C101044
CTD	decreases(reaction)			MUC5AC		C101044
CTD	increases(expression)			MUC5AC		C101044
CTD	decreases(reaction)			MUC5AC		C101044
CTD	increases(expression)			MUC5AC		C101044
CTD	affects(cotreatment)			NFE2L2		C101044
CTD	affects(localization)			NFE2L2		C101044
CTD	decreases(reaction)			NFE2L2		C101044
CTD	increases(expression)			NFKBIA		C101044
CTD	decreases(activity)			NOS3		C101044
CTD	decreases(reaction)			NOS3		C101044
CTD	increases(activity)			NOS3		C101044
CTD	increases(phosphorylation)			NOS3		C101044
CTD	decreases(expression)			NOTCH1		C101044
CTD	decreases(reaction)			NOTCH1		C101044
CTD	increases(expression)			NOTCH1		C101044
CTD	decreases(reaction)			NTS		C101044
CTD	increases(expression)			NTS		C101044
CTD	decreases(reaction)			NTS		C101044
CTD	increases(activity)			NTS		C101044
CTD	increases(phosphorylation)			NTS		C101044
CTD	decreases(reaction)			NTS		C101044
CTD	increases(activity)			NTS		C101044
CTD	increases(phosphorylation)			NTS		C101044
CTD	increases(secretion)			NTS		C101044
CTD	decreases(expression)			PCNA		C101044
CTD	decreases(reaction)			PLA2G4A		C101044
CTD	increases(expression)			PLA2G4A		C101044
CTD	increases(secretion)			PLA2G4A		C101044
CTD	decreases(reaction)			PPARD		C101044
CTD	increases(expression)			PPARD		C101044
CTD	affects(expression)			PRKCD		C101044
CTD	decreases(reaction)			PRKCD		C101044
CTD	decreases(phosphorylation)			PRKCD		C101044
CTD	decreases(reaction)			PTGS2		C101044
CTD	increases(expression)			PTGS2		C101044
CTD	increases(secretion)			PTGS2		C101044
CTD	decreases(reaction)			SRC		C101044
CTD	increases(phosphorylation)			SRC		C101044
CTD	decreases(reaction)			STAT3		C101044
CTD	increases(expression)			STAT3		C101044
CTD	decreases(activity)			STAT5B		C101044
CTD	decreases(reaction)			STAT5B		C101044
CTD	increases(activity)			STAT5B		C101044
CTD	increases(phosphorylation)			STAT5B		C101044
CTD	decreases(reaction)			TAC1		C101044
CTD	increases(activity)			TAC1		C101044
CTD	increases(phosphorylation)			TAC1		C101044
CTD	affects(localization)			TFAP2A		C101044
CTD	decreases(reaction)			TFAP2A		C101044
CTD	decreases(reaction)			TGFA		C101044
CTD	increases(expression)			TGFA		C101044
CTD	decreases(reaction)			TGFA		C101044
CTD	increases(activity)			TGFA		C101044
CTD	increases(phosphorylation)			TGFA		C101044
CTD	decreases(reaction)			TNF		C101044
CTD	increases(secretion)			TNF		C101044
CTD	decreases(reaction)			TP53		C101044
CTD	increases(expression)			TP53		C101044
CTD	decreases(reaction)			VEGFA		C101044
CTD	increases(secretion)			VEGFA		C101044
PubChem	Potency	uM	0.316	MAPK1	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
ChEMBL	Potency	nM	316.200	MAPK1	-	Target : CHEMBL4040

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