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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide

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Collection	D4 : CTD
Chemical Name	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide ( From PubChem : TYRPHOSTIN B42 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 294.305 g/mol 3 5 2.71208 True
Structure
InChI	InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKey	TUCIOBMMDDOEMM-RIYZIHGNSA-N
Links
Gene (58 / 179) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD affects(cotreatment) AGT C095512 CTD decreases(reaction) AGT C095512 CTD increases(phosphorylation) AGT C095512 CTD decreases(phosphorylation) AKT1 C095512 CTD increases(expression) BAD C095512 CTD increases(expression) BAX C095512 CTD decreases(expression) BCL2 C095512 CTD decreases(expression) BCL2L1 C095512 CTD decreases(reaction) BIRC3 C095512 CTD increases(expression) BIRC3 C095512 CTD decreases(reaction) BIRC3 C095512 CTD increases(expression) BIRC3 C095512 CTD decreases(expression) BIRC5 C095512 CTD decreases(expression) BIRC5 C095512 CTD decreases(phosphorylation) BIRC5 C095512 CTD affects(cotreatment) CASP3 C095512 CTD decreases(activity) CASP3 C095512 CTD decreases(reaction) CASP3 C095512 CTD decreases(expression) CASP3 C095512 CTD decreases(reaction) CCL2 C095512 CTD increases(expression) CCL2 C095512 CTD decreases(reaction) CCND1 C095512 CTD increases(expression) CCND1 C095512 CTD decreases(expression) CCND1 C095512 CTD decreases(phosphorylation) CCND1 C095512 CTD decreases(reaction) CCND3 C095512 CTD increases(expression) CCND3 C095512 CTD decreases(expression) CFTR C095512 CTD decreases(reaction) CFTR C095512 CTD decreases(expression) CREBBP C095512 CTD decreases(reaction) CREBBP C095512 CTD decreases(reaction) CSF3 C095512 CTD increases(expression) CSF3 C095512 CTD increases(phosphorylation) CSF3 C095512 CTD decreases(reaction) CYP27B1 C095512 CTD increases(expression) CYP27B1 C095512 CTD decreases(reaction) EGFR C095512 CTD increases(expression) EGFR C095512 CTD decreases(reaction) ICAM1 C095512 CTD increases(expression) ICAM1 C095512 CTD decreases(reaction) ICAM1 C095512 CTD increases(expression) ICAM1 C095512 CTD decreases(reaction) IFNA1 C095512 CTD increases(expression) IFNA1 C095512 CTD decreases(reaction) IFNA1 C095512 CTD increases(expression) IFNA1 C095512 CTD increases(phosphorylation) IFNA1 C095512 CTD increases(phosphorylation) IFNA1 C095512 CTD decreases(reaction) IFNB1 C095512 CTD increases(expression) IFNB1 C095512 CTD increases(phosphorylation) IFNB1 C095512 CTD decreases(reaction) IFNG C095512 CTD increases(expression) IFNG C095512 CTD decreases(reaction) IFNG C095512 CTD increases(expression) IFNG C095512 CTD decreases(reaction) IFNG C095512 CTD increases(expression) IFNG C095512 CTD decreases(reaction) IFNG C095512 CTD increases(expression) IFNG C095512 CTD decreases(reaction) IFNG C095512 CTD increases(phosphorylation) IFNG C095512 CTD increases(phosphorylation) IFNG C095512 CTD decreases(response to substance) IFNG C095512 CTD increases(activity) IFNG C095512 CTD decreases(expression) IL6 C095512 CTD decreases(reaction) IL6 C095512 CTD decreases(reaction) IRF1 C095512 CTD increases(expression) IRF1 C095512 CTD decreases(reaction) JAK2 C095512 CTD increases(activity) JAK2 C095512 CTD increases(phosphorylation) JAK2 C095512 CTD affects(cotreatment) JAK2 C095512 CTD decreases(activity) JAK2 C095512 CTD decreases(reaction) JAK2 C095512 CTD decreases(expression) JAK2 C095512 CTD decreases(activity) JAK2 C095512 CTD decreases(response to substance) JAK2 C095512 CTD decreases(phosphorylation) JAK2 C095512 CTD affects(cotreatment) LEP C095512 CTD decreases(activity) LEP C095512 CTD decreases(reaction) LEP C095512 CTD decreases(expression) LEP C095512 CTD decreases(reaction) LY96 C095512 CTD increases(expression) LY96 C095512 CTD decreases(activity) MAPK1 C095512 CTD decreases(reaction) MAPK1 C095512 CTD decreases(activity) MAPK3 C095512 CTD decreases(reaction) MAPK3 C095512 CTD decreases(reaction) MCL1 C095512 CTD increases(expression) MCL1 C095512 CTD decreases(expression) MCL1 C095512 CTD decreases(expression) MYC C095512 CTD decreases(phosphorylation) MYC C095512 CTD decreases(expression) PTGS2 C095512 CTD decreases(phosphorylation) PTGS2 C095512 CTD affects(binding) RELA C095512 CTD affects(cotreatment) RELA C095512 CTD decreases(reaction) RELA C095512 CTD increases(reaction) RELA C095512 CTD decreases(phosphorylation) SRC C095512 CTD decreases(reaction) STAT1 C095512 CTD increases(phosphorylation) STAT1 C095512 CTD decreases(reaction) STAT1 C095512 CTD increases(phosphorylation) STAT1 C095512 CTD decreases(reaction) STAT1 C095512 CTD increases(phosphorylation) STAT1 C095512 CTD affects(binding) STAT3 C095512 CTD affects(cotreatment) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(reaction) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(activity) STAT3 C095512 CTD increases(expression) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD affects(localization) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(activity) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD affects(cotreatment) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD decreases(reaction) STAT3 C095512 CTD increases(phosphorylation) STAT3 C095512 CTD decreases(activity) STAT3 C095512 CTD decreases(phosphorylation) STAT3 C095512 CTD decreases(expression) STAT3 C095512 CTD decreases(phosphorylation) STAT3 C095512 CTD decreases(reaction) TNF C095512 CTD increases(expression) TNF C095512 CTD increases(phosphorylation) TNF C095512 CTD decreases(activity) TNF C095512 CTD decreases(response to substance) TNF C095512 CTD decreases(reaction) TYMP C095512 CTD increases(expression) TYMP C095512 CTD decreases(reaction) VCAM1 C095512 CTD increases(expression) VCAM1 C095512 PubChem None uM ALPI - GI(Protien) : PubChem Potency uM 12.589 BAZ2B - GI(Protien) : PubChem Potency uM 10.000 CBX1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 15.849 CYP3A4 - GI(Protien) : PubChem None uM CYP3A4 - GI(Protien) : PubChem Potency uM 4.744 EHMT2 - GI(Protien) : PubChem Potency uM 5.012 EHMT2 - GI(Protien) : PubChem Potency uM 5.623 EHMT2 - GI(Protien) : PubChem Potency uM 0.562 GLS - GI(Protien) : PubChem Potency uM 8.912 GMNN - GI(Protien) : PubChem Potency uM 10.000 HIF1A - GI(Protien) : PubChem None uM HSP90AA1 - GI(Protien) : PubChem Potency uM 25.119 HSPA5 - GI(Protien) : PubChem None uM IDE - GI(Protien) : PubChem None uM IDE - GI(Protien) : PubChem Potency uM 12.589 KCNH2 GI(Protien) : PubChem Potency uM 12.589 KCNH2 GI(Protien) : PubChem None uM PLA2G7 - GI(Protien) : PubChem Potency uM 11.220 POLH - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 29.855 TDP1 - GI(Protien) : ChEMBL Potency nM 12589.300 BAZ2B - Target : CHEMBL1741220 ChEMBL Potency nM 10000.000 CBX1 - Target : CHEMBL1741193 ChEMBL AC50 nM 7943.280 CYP1A2 - Target : CHEMBL3356 ChEMBL AC50 nM 15848.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 15848.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 5623.400 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 5011.900 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 4744.400 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 8912.500 GMNN - Target : CHEMBL1293278 ChEMBL Potency nM 10000.000 HIF1A - Target : CHEMBL4261 ChEMBL Potency nM 15848.900 HSD17B10 - Target : CHEMBL4159 ChEMBL Inhibition - JAK2 - Target : CHEMBL2971 ChEMBL Potency nM 15848.900 KDM4E - Target : CHEMBL1293226 ChEMBL Potency nM 19952.600 KDM4E - Target : CHEMBL1293226 ChEMBL Potency nM 31622.800 RECQL - Target : CHEMBL1293236
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