Tan Lab | DSigDB

Gene Set: D4 : CTD - tazarotene

Collection

D4 : CTD

Chemical Name

tazarotene ( From PubChem : TAZAROTENE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
351.462 g/mol	0	4	4.4315	True

Structure

InChI

InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

InChIKey

Links

Gene (15 / 24)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BAX		C086827
CTD	decreases(expression)			BCL2		C086827
CTD	increases(activity)			CASP3		C086827
CTD	affects(cotreatment)			MAPK1		C086827
CTD	increases(activity)			MAPK1		C086827
CTD	increases(phosphorylation)			MAPK1		C086827
CTD	affects(cotreatment)			MAPK3		C086827
CTD	increases(activity)			MAPK3		C086827
CTD	increases(phosphorylation)			MAPK3		C086827
CTD	affects(binding)			RARB		C086827
CTD	increases(activity)			RARB		C086827
CTD	affects(binding)			RARG		C086827
CTD	increases(activity)			RARG		C086827
CTD	affects(cotreatment)			RB1		C086827
CTD	decreases(phosphorylation)			RB1		C086827
CTD	increases(expression)			SLC5A5		C086827
CTD	increases(activity)			STS		C086827
CTD	decreases(reaction)			STS		C086827
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.075	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.075	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.601	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	27.642	NR1H4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	29.847	PPARD	-	GI(Protien) :

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