Tan Lab | DSigDB

Gene Set: D4 : CTD - fipronil

Collection

D4 : CTD

Chemical Name

fipronil ( From PubChem : FIPRONIL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
437.148 g/mol	1	5	5.72608	False(3/4)

Structure

InChI

InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2/t26-/m0/s1

InChIKey

ZOCSXAVNDGMNBV-SANMLTNESA-N

Links

Gene (24 / 50)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			BCL2		C082360
CTD	increases(activity)			CASP3		C082360
CTD	decreases(reaction)			CASP3		C082360
CTD	increases(activity)			CASP3		C082360
CTD	increases(activity)			CASP7		C082360
CTD	increases(activity)			CASP9		C082360
CTD	affects(localization)			CYCS		C082360
CTD	affects(activity)			CYP1A1		C082360
CTD	increases(expression)			CYP1A1		C082360
CTD	increases(expression)			CYP2B6		C082360
CTD	increases(oxidation)			CYP3A		C082360
CTD	increases(chemical synthesis)			CYP3A4		C082360
CTD	increases(metabolic processing)			CYP3A4		C082360
CTD	increases(reaction)			CYP3A4		C082360
CTD	increases(activity)			CYP3A4		C082360
CTD	increases(expression)			CYP3A4		C082360
CTD	increases(expression)			CYP3A5		C082360
CTD	affects(binding)			GABRB1		C082360
CTD	affects(binding)			GABRB3		C082360
CTD	affects(binding)			GABRB3		C082360
CTD	decreases(reaction)			GABRB3		C082360
CTD	decreases(activity)			GLRA1		C082360
CTD	decreases(activity)			GLRA2		C082360
CTD	decreases(activity)			GLRA3		C082360
CTD	decreases(phosphorylation)			GSK3B		C082360
CTD	affects(response to substance)			GSK3B		C082360
CTD	decreases(reaction)			GSK3B		C082360
CTD	increases(activity)			NR1I2		C082360
CTD	decreases(expression)			TH		C082360
CTD	affects(localization)			TP53		C082360
PubChem	AR Potency (uM)	uM	1.144	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.334	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	20.210	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.449	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	33.492	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.498	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	15.449	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	16.785	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.478	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.162	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.485	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.735	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	61.131	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	12.589	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	5.309	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.573	TDP1	-	GI(Protien) :
PubChem	Potency	uM	9.441	TDP1	-	GI(Protien) :
PubChem	Potency	uM	9.620	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :

Download gene sets

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