Tan Lab | DSigDB

Gene Set: D4 : CTD - irbesartan

Collection

D4 : CTD

Chemical Name

irbesartan ( From PubChem : IRBESARTAN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
428.529 g/mol	1	6	4.1509	True

Structure

InChI

InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChIKey

YOSHYTLCDANDAN-UHFFFAOYSA-N

Links

Gene (20 / 28)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB11		C081309
CTD	affects(response to substance)			ACE2		C081309
CTD	affects(response to substance)			AGT		C081309
CTD	affects(response to substance)			AGT		C081309
CTD	decreases(reaction)			AGT		C081309
CTD	increases(response to substance)			AGT		C081309
CTD	increases(expression)			AGT		C081309
CTD	affects(response to substance)			AGTR1		C081309
CTD	affects(binding)			AGTR1		C081309
CTD	decreases(activity)			AGTR1		C081309
CTD	affects(response to substance)			APOB		C081309
CTD	affects(response to substance)			BDKRB2		C081309
CTD	decreases(activity)			CA1		C081309
CTD	increases(response to substance)			CYP11B2		C081309
CTD	decreases(activity)			CYP2C8		C081309
CTD	decreases(response to substance)			CYP2C9		C081309
CTD	increases(metabolic processing)			CYP2C9		C081309
CTD	affects(response to substance)			EDN1		C081309
CTD	affects(response to substance)			ERAP1		C081309
CTD	decreases(expression)			IFNG		C081309
CTD	increases(expression)			NPPA		C081309
CTD	increases(expression)			REN		C081309
CTD	increases(expression)			RET		C081309
CTD	affects(response to substance)			TGFB1		C081309
CTD	decreases(expression)			TNF		C081309
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.521	PPARG	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340

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