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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide

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Collection	D4 : CTD
Chemical Name	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide ( From PubChem : NS-398 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 314.357 g/mol 1 4 4.3548 True
Structure
InChI	InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChIKey	KTDZCOWXCWUPEO-UHFFFAOYSA-N
Links
Gene (74 / 261) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) ABCB1 C080955 CTD decreases(expression) ABCB1 C080955 CTD increases(expression) ABCB1 C080955 CTD increases(expression) ABCC1 C080955 CTD increases(expression) ACE C080955 CTD increases(reaction) ACE C080955 CTD decreases(reaction) ALOX15 C080955 CTD increases(activity) ALOX15 C080955 CTD decreases(reaction) ALOX15 C080955 CTD increases(expression) ALOX15 C080955 CTD increases(expression) ALOX15 C080955 CTD increases(chemical synthesis) ALOX15 C080955 CTD increases(expression) ALOX15 C080955 CTD affects(cotreatment) BAX C080955 CTD increases(expression) BAX C080955 CTD affects(cotreatment) BCL2 C080955 CTD decreases(expression) BCL2 C080955 CTD decreases(reaction) CASP3 C080955 CTD increases(cleavage) CASP3 C080955 CTD increases(activity) CASP3 C080955 CTD decreases(reaction) CASP3 C080955 CTD increases(activity) CASP8 C080955 CTD increases(activity) CASP9 C080955 CTD decreases(reaction) CASP9 C080955 CTD decreases(abundance) CAT C080955 CTD decreases(reaction) CAT C080955 CTD decreases(expression) CAT C080955 CTD decreases(expression) CAV1 C080955 CTD decreases(reaction) CCL2 C080955 CTD increases(secretion) CCL2 C080955 CTD decreases(reaction) CCL2 C080955 CTD increases(secretion) CCL2 C080955 CTD decreases(expression) CCNB1 C080955 CTD decreases(expression) CCND1 C080955 CTD decreases(expression) CCNK C080955 CTD decreases(activity) CDK2 C080955 CTD increases(reaction) CDK2 C080955 CTD affects(reaction) CDK2 C080955 CTD decreases(reaction) CDKN1A C080955 CTD increases(expression) CDKN1A C080955 CTD decreases(activity) CDKN1A C080955 CTD increases(reaction) CDKN1A C080955 CTD increases(activity) CDKN1A C080955 CTD increases(expression) CDKN1A C080955 CTD increases(expression) CDKN1B C080955 CTD decreases(activity) CGB C080955 CTD decreases(reaction) CGB C080955 CTD increases(chemical synthesis) CGB C080955 CTD decreases(reaction) CXCL10 C080955 CTD increases(secretion) CXCL10 C080955 CTD affects(cotreatment) CXCL8 C080955 CTD decreases(expression) CXCL8 C080955 CTD decreases(reaction) CXCL8 C080955 CTD increases(expression) CXCL8 C080955 CTD decreases(reaction) CXCL8 C080955 CTD increases(reaction) CXCL8 C080955 CTD increases(secretion) CXCL8 C080955 CTD decreases(activity) CXCL8 C080955 CTD decreases(reaction) CXCL8 C080955 CTD increases(secretion) CXCL8 C080955 CTD decreases(secretion) CXCL8 C080955 CTD decreases(activity) CYP19A1 C080955 CTD decreases(expression) CYP19A1 C080955 CTD decreases(reaction) CYP19A1 C080955 CTD increases(expression) CYP19A1 C080955 CTD decreases(activity) CYP19A1 C080955 CTD decreases(expression) CYP19A1 C080955 CTD decreases(reaction) CYP1B1 C080955 CTD increases(expression) CYP1B1 C080955 CTD decreases(expression) DDIT3 C080955 CTD increases(expression) DNM2 C080955 CTD decreases(reaction) EGR1 C080955 CTD increases(expression) EGR1 C080955 CTD decreases(activity) F2 C080955 CTD affects(cotreatment) FASLG C080955 CTD increases(localization) FASLG C080955 CTD increases(stability) FASLG C080955 CTD increases(expression) FAT1 C080955 CTD decreases(reaction) GATA6 C080955 CTD increases(expression) GATA6 C080955 CTD decreases(expression) GATA6 C080955 CTD increases(expression) GDF15 C080955 CTD increases(expression) GPX1 C080955 CTD decreases(reaction) H2AFX C080955 CTD increases(phosphorylation) H2AFX C080955 CTD decreases(reaction) HGF C080955 CTD increases(activity) HGF C080955 CTD increases(expression) HGF C080955 CTD decreases(expression) HGF C080955 CTD decreases(reaction) HIF1A C080955 CTD increases(expression) HIF1A C080955 CTD decreases(reaction) HMOX1 C080955 CTD increases(expression) HMOX1 C080955 CTD decreases(reaction) IL1A C080955 CTD increases(secretion) IL1A C080955 CTD decreases(reaction) IL1B C080955 CTD increases(expression) IL1B C080955 CTD decreases(reaction) IL1B C080955 CTD increases(abundance) IL1B C080955 CTD decreases(reaction) IL1B C080955 CTD increases(abundance) IL1B C080955 CTD decreases(reaction) IL1B C080955 CTD increases(expression) IL1B C080955 CTD decreases(reaction) IL1B C080955 CTD increases(secretion) IL1B C080955 CTD increases(reaction) IL1B C080955 CTD decreases(reaction) IL6 C080955 CTD increases(expression) IL6 C080955 CTD decreases(reaction) IL6 C080955 CTD increases(secretion) IL6 C080955 CTD increases(reaction) IL6 C080955 CTD increases(secretion) IL6 C080955 CTD decreases(activity) IL6 C080955 CTD decreases(reaction) IL6 C080955 CTD increases(secretion) IL6 C080955 CTD decreases(expression) IL6 C080955 CTD increases(reaction) INS C080955 CTD increases(secretion) INS C080955 CTD decreases(expression) ITGA5 C080955 CTD decreases(reaction) ITGA5 C080955 CTD decreases(expression) JUN C080955 CTD decreases(expression) KIAA0101 C080955 CTD decreases(reaction) MAPK1 C080955 CTD increases(phosphorylation) MAPK1 C080955 CTD decreases(expression) MAPK1 C080955 CTD decreases(reaction) MAPK1 C080955 CTD decreases(reaction) MAPK1 C080955 CTD increases(activity) MAPK1 C080955 CTD increases(phosphorylation) MAPK1 C080955 CTD decreases(reaction) MAPK3 C080955 CTD increases(phosphorylation) MAPK3 C080955 CTD decreases(expression) MAPK3 C080955 CTD decreases(reaction) MAPK3 C080955 CTD decreases(reaction) MAPK3 C080955 CTD increases(activity) MAPK3 C080955 CTD increases(phosphorylation) MAPK3 C080955 CTD decreases(phosphorylation) MAPK9 C080955 CTD decreases(reaction) MMP9 C080955 CTD increases(expression) MMP9 C080955 CTD decreases(reaction) MMP9 C080955 CTD increases(expression) MMP9 C080955 CTD decreases(reaction) MMP9 C080955 CTD increases(activity) MMP9 C080955 CTD increases(expression) MMP9 C080955 CTD decreases(expression) NFKBIA C080955 CTD increases(expression) PAWR C080955 CTD increases(expression) PCDH7 C080955 CTD increases(expression) PDCD4 C080955 CTD decreases(reaction) PDGFA C080955 CTD increases(abundance) PDGFA C080955 CTD increases(expression) PDLIM5 C080955 CTD decreases(reaction) PPARA C080955 CTD increases(expression) PPARA C080955 CTD decreases(expression) PPARA C080955 CTD affects(localization) PPARG C080955 CTD decreases(reaction) PPARG C080955 CTD affects(localization) PPARG C080955 CTD decreases(reaction) PPARG C080955 CTD decreases(reaction) PPARG C080955 CTD increases(expression) PPARG C080955 CTD decreases(expression) PPARG C080955 CTD increases(localization) PPARG C080955 CTD increases(expression) PPFIA1 C080955 CTD decreases(expression) PTGER2 C080955 CTD decreases(activity) PTGS1 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(activity) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(activity) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD increases(chemical synthesis) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(activity) PTGS2 C080955 CTD increases(chemical synthesis) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD increases(reaction) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(chemical synthesis) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(secretion) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(activity) PTGS2 C080955 CTD affects(response to substance) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(abundance) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(response to substance) PTGS2 C080955 CTD decreases(expression) PTGS2 C080955 CTD decreases(expression) PTGS2 C080955 CTD decreases(expression) PTGS2 C080955 CTD increases(expression) PTGS2 C080955 CTD affects(reaction) PTGS2 C080955 CTD decreases(activity) PTGS2 C080955 CTD decreases(reaction) PTGS2 C080955 CTD increases(activity) PTGS2 C080955 CTD increases(response to substance) PTGS2 C080955 CTD decreases(reaction) SOD2 C080955 CTD increases(expression) SOD2 C080955 CTD decreases(expression) SOD2 C080955 CTD increases(expression) SP1 C080955 CTD decreases(reaction) TIMP1 C080955 CTD increases(expression) TIMP1 C080955 CTD decreases(reaction) TNF C080955 CTD increases(secretion) TNF C080955 CTD increases(expression) TNF C080955 CTD increases(reaction) TNF C080955 CTD increases(reaction) TNF C080955 CTD increases(secretion) TNF C080955 CTD increases(expression) TNFRSF10A C080955 CTD increases(expression) TNFRSF10B C080955 CTD increases(localization) TNFRSF10B C080955 CTD increases(reaction) TNFRSF10B C080955 CTD affects(cotreatment) TNFRSF10B C080955 CTD increases(response to substance) TNFRSF10B C080955 CTD increases(expression) TNFRSF10B C080955 CTD affects(cotreatment) TNFSF10 C080955 CTD increases(expression) TNFSF10 C080955 CTD increases(localization) TNFSF10 C080955 CTD increases(reaction) TNFSF10 C080955 CTD increases(response to substance) TNFSF10 C080955 CTD decreases(reaction) TP53 C080955 CTD increases(phosphorylation) TP53 C080955 CTD decreases(activity) TP53 C080955 CTD decreases(reaction) TP53 C080955 CTD increases(activity) TP53 C080955 CTD decreases(expression) TPX2 C080955 CTD decreases(reaction) VEGFA C080955 CTD increases(expression) VEGFA C080955 CTD decreases(reaction) VEGFA C080955 CTD increases(expression) VEGFA C080955 CTD increases(expression) VEGFA C080955 CTD increases(reaction) VEGFA C080955 PubChem Potency uM 22.387 ALDH1A1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 0.079 CYP2C19 - GI(Protien) : PubChem None uM CYP2C19 - GI(Protien) : PubChem Potency uM 0.050 CYP2D6 - GI(Protien) : PubChem None uM CYP2D6 - GI(Protien) : PubChem Potency uM 8.437 RGS4 - GI(Protien) : ChEMBL Potency nM 22387.200 ALDH1A1 - Target : CHEMBL3577 ChEMBL AC50 nM 3981.070 CYP1A2 - Target : CHEMBL3356 ChEMBL AC50 nM 79.430 CYP2C19 - Target : CHEMBL3622 ChEMBL Potency nM 79.400 CYP2C19 - Target : CHEMBL3622 ChEMBL AC50 nM 50.120 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 50.100 CYP2D6 - Target : CHEMBL289 ChEMBL Inhibition - PTGS2 - Target : CHEMBL230 ChEMBL Activity - PTGS2 - Target : CHEMBL230 ChEMBL Inhibition - PTGS2 - Target : CHEMBL230
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