Tan Lab | DSigDB

Gene Set: D4 : CTD - rubitecan

Collection

D4 : CTD

Chemical Name

rubitecan ( From PubChem : RUBITECAN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
393.35 g/mol	1	6	2.511	True

Structure

InChI

InChI=1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1

InChIKey

Links

Gene (18 / 36)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCC2		C079905
CTD	affects(cotreatment)			AIFM1		C079905
CTD	increases(expression)			AIFM1		C079905
CTD	affects(cotreatment)			BAX		C079905
CTD	increases(expression)			BAX		C079905
CTD	affects(cotreatment)			BCL2		C079905
CTD	decreases(expression)			BCL2		C079905
CTD	affects(cotreatment)			CASP3		C079905
CTD	increases(expression)			CASP3		C079905
CTD	affects(cotreatment)			CASP8		C079905
CTD	increases(expression)			CASP8		C079905
CTD	affects(cotreatment)			CASP9		C079905
CTD	increases(expression)			CASP9		C079905
CTD	affects(cotreatment)			CCND1		C079905
CTD	decreases(expression)			CCND1		C079905
CTD	decreases(expression)			CCNE1		C079905
CTD	increases(reaction)			CCNE1		C079905
CTD	affects(cotreatment)			CDK2		C079905
CTD	decreases(expression)			CDK2		C079905
CTD	affects(cotreatment)			CDKN1A		C079905
CTD	increases(expression)			CDKN1A		C079905
CTD	affects(cotreatment)			CDKN1B		C079905
CTD	increases(expression)			CDKN1B		C079905
CTD	decreases(reaction)			TP53		C079905
CTD	increases(expression)			TP53		C079905
PubChem	Potency-Replicate_1	uM	0.190	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.422	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	0.438	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.596	CYP19A1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.246	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.266	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.294	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.772	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.739	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.034	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.211	TDP1	-	GI(Protien) :

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