Tan Lab | DSigDB

Gene Set: D4 : CTD - olanzapine

Collection

D4 : CTD

Chemical Name

olanzapine ( From PubChem : OLANZAPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
312.432 g/mol	1	5	1.1958	True

Structure

InChI

InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3

InChIKey

WXPNDRBBWZMPQG-UHFFFAOYSA-N

Links

Gene (43 / 86)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		C076029
CTD	decreases(activity)			ABCB11		C076029
CTD	decreases(reaction)			ABCG2		C076029
CTD	increases(transport)			ABCG2		C076029
CTD	affects(cotreatment)			AKT1		C076029
CTD	increases(response to substance)			AKT1		C076029
CTD	increases(expression)			AKT1		C076029
CTD	increases(phosphorylation)			AKT1		C076029
CTD	affects(response to substance)			AQP4		C076029
CTD	increases(response to substance)			AQP4		C076029
CTD	increases(expression)			BIK		C076029
CTD	affects(binding)			CHRM1		C076029
CTD	affects(metabolic processing)			CYP1A2		C076029
CTD	affects(metabolic processing)			CYP1A2		C076029
CTD	decreases(reaction)			CYP1A2		C076029
CTD	increases(response to substance)			DRD2		C076029
CTD	affects(cotreatment)			DRD2		C076029
CTD	increases(response to substance)			DRD2		C076029
CTD	affects(activity)			DRD2		C076029
CTD	affects(binding)			DRD2		C076029
CTD	decreases(activity)			DRD2		C076029
CTD	affects(cotreatment)			DRD3		C076029
CTD	increases(response to substance)			DRD3		C076029
CTD	increases(phosphorylation)			GSK3B		C076029
CTD	increases(expression)			HMGCR		C076029
CTD	increases(expression)			HMGCS1		C076029
CTD	affects(cotreatment)			HRH1		C076029
CTD	increases(response to substance)			HRH1		C076029
CTD	affects(binding)			HRH1		C076029
CTD	affects(binding)			HTR2A		C076029
CTD	decreases(activity)			HTR2A		C076029
CTD	affects(binding)			HTR2A		C076029
CTD	affects(response to substance)			HTR2C		C076029
CTD	increases(response to substance)			HTR2C		C076029
CTD	affects(response to substance)			HTR2C		C076029
CTD	affects(response to substance)			HTR2C		C076029
CTD	affects(binding)			HTR2C		C076029
CTD	affects(binding)			HTR6		C076029
CTD	increases(expression)			INS		C076029
CTD	increases(secretion)			INS		C076029
CTD	decreases(reaction)			KCNH2		C076029
CTD	increases(transport)			KCNH2		C076029
CTD	decreases(activity)			KCNH2		C076029
CTD	increases(expression)			LDLR		C076029
CTD	increases(expression)			LEP		C076029
CTD	affects(response to substance)			MTHFR		C076029
CTD	affects(cotreatment)			PRL		C076029
CTD	increases(expression)			PRL		C076029
CTD	increases(expression)			PRL		C076029
CTD	increases(secretion)			PRL		C076029
CTD	increases(expression)			SC5D		C076029
CTD	decreases(expression)			SHBG		C076029
CTD	decreases(reaction)			SLC22A2		C076029
CTD	increases(uptake)			SLC22A2		C076029
CTD	increases(expression)			SLC2A4		C076029
CTD	affects(response to substance)			SNAP25		C076029
CTD	increases(activity)			SREBF2		C076029
CTD	increases(cleavage)			SREBF2		C076029
CTD	increases(expression)			TP53		C076029
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	Potency	uM	5.623	GAA	-	GI(Protien) :
PubChem	AC50_uM	uM	0.369	GFER	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1B		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1E		GI(Protien) :
PubChem	None	uM		HTR1F		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
ChEMBL	Potency	nM	5623.400	GAA	-	Target : CHEMBL2608
ChEMBL	AC50	nM	369.000	GFER	-	Target : CHEMBL1741189

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