Tan Lab | DSigDB

Gene Set: D4 : CTD - norcantharidin

Collection

D4 : CTD

Chemical Name

norcantharidin ( From PubChem : NORCANTHARIDIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
168.147 g/mol	0	4	-0.1366	True

Structure

InChI

InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4+,5-,6+

InChIKey

Links

Gene (27 / 35)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ANGPT2		C069741
CTD	increases(expression)			BAD		C069741
CTD	increases(expression)			BAX		C069741
CTD	increases(phosphorylation)			BCL2		C069741
CTD	decreases(expression)			BCL2L1		C069741
CTD	increases(activity)			CASP3		C069741
CTD	increases(activity)			CASP8		C069741
CTD	increases(activity)			CASP9		C069741
CTD	decreases(expression)			CDC25C		C069741
CTD	increases(phosphorylation)			CDKN1A		C069741
CTD	increases(phosphorylation)			CHEK1		C069741
CTD	increases(phosphorylation)			CHEK2		C069741
CTD	increases(expression)			FAS		C069741
CTD	affects(cotreatment)			IL2		C069741
CTD	decreases(reaction)			IL2		C069741
CTD	increases(secretion)			IL2		C069741
CTD	increases(phosphorylation)			MAPK1		C069741
CTD	increases(phosphorylation)			MAPK3		C069741
CTD	increases(phosphorylation)			MAPK8		C069741
CTD	decreases(expression)			MCL1		C069741
CTD	decreases(expression)			PCNA		C069741
CTD	decreases(phosphorylation)			STAT3		C069741
CTD	decreases(phosphorylation)			STAT5A		C069741
CTD	increases(expression)			THBS1		C069741
CTD	increases(expression)			TIMP2		C069741
CTD	decreases(expression)			VEGFA		C069741
PubChem	IC50	uM	2.832	PPP1CA	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	IC50	uM	2.567	PPP5C	-	GI(Protien) :
PubChem	None	uM		PPP5C	-	GI(Protien) :
PubChem	None	uM		PPP5C	-	GI(Protien) :
ChEMBL	Potency	nM	22387.200	KDM4E	-	Target : CHEMBL1293226
ChEMBL	IC50	nM	2832.000	PPP1CA	-	Target : CHEMBL2164
ChEMBL	IC50	nM	2567.000	PPP5C	-	Target : CHEMBL1293265

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