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Gene Set: D4 : CTD - clofarabine


Collection D4 : CTD
Chemical Name clofarabine ( From PubChem : CLOFARABINE )
FDA NPC WHO Indian Australia China Traditional
Herbal
Clinical
Trail
ApprovedNotNotNotNotNotNotNot
Molecular
Weight
Hydrogen Bond
Donor Count
Hydrogen Bond
Acceptor Count
cLogP Lipinski Rule
303.677 g/mol 3 8 0.2318 True
Structure
InChI InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKey WDDPHFBMKLOVOX-AYQXTPAHSA-N
Links

Gene (23 / 55)


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Source Type Unit Value Gene PMID Assay Other
CTDaffects(cotreatment)ANP32B
C068329
CTDincreases(cleavage)ANP32B
C068329
CTDaffects(cotreatment)ATM
C068329
CTDincreases(phosphorylation)ATM
C068329
CTDaffects(cotreatment)CASP3
C068329
CTDincreases(cleavage)CASP3
C068329
CTDaffects(cotreatment)CASP3
C068329
CTDincreases(expression)CASP3
C068329
CTDaffects(cotreatment)CASP9
C068329
CTDincreases(cleavage)CASP9
C068329
CTDaffects(cotreatment)CCND1
C068329
CTDdecreases(expression)CCND1
C068329
CTDaffects(cotreatment)CDC25B
C068329
CTDincreases(phosphorylation)CDC25B
C068329
CTDaffects(cotreatment)CDKN1A
C068329
CTDdecreases(expression)CDKN1A
C068329
CTDincreases(reaction)CDKN1A
C068329
CTDaffects(cotreatment)CDKN1A
C068329
CTDincreases(expression)CDKN1A
C068329
CTDaffects(cotreatment)CHEK1
C068329
CTDincreases(phosphorylation)CHEK1
C068329
CTDaffects(cotreatment)CHEK2
C068329
CTDincreases(phosphorylation)CHEK2
C068329
CTDaffects(cotreatment)H2AFX
C068329
CTDincreases(expression)H2AFX
C068329
CTDaffects(cotreatment)MET
C068329
CTDdecreases(expression)MET
C068329
CTDaffects(cotreatment)MYC
C068329
CTDdecreases(expression)MYC
C068329
CTDaffects(cotreatment)PARP1
C068329
CTDincreases(cleavage)PARP1
C068329
CTDaffects(cotreatment)PARP1
C068329
CTDincreases(expression)PARP1
C068329
CTDaffects(cotreatment)SMC1A
C068329
CTDincreases(phosphorylation)SMC1A
C068329
CTDaffects(cotreatment)SMC3
C068329
CTDincreases(phosphorylation)SMC3
C068329
CTDaffects(cotreatment)SP1
C068329
CTDaffects(localization)SP1
C068329
CTDdecreases(expression)SP1
C068329
CTDaffects(cotreatment)TP53
C068329
CTDaffects(localization)TP53
C068329
CTDincreases(activity)TP53
C068329
CTDincreases(expression)TP53
C068329
CTDaffects(response to substance)TP53
C068329
CTDaffects(cotreatment)XIAP
C068329
CTDdecreases(expression)XIAP
C068329
PubChem Ratio Potency (uM)uM10.682AR-GI(Protien) :
PubChem Potency-Replicate_1uM13.448AR-GI(Protien) :
PubChem NoneuMCYP19A1-GI(Protien) :
PubChem Potency-Replicate_1uM3.758ESR1-GI(Protien) :
PubChem ER Potency (uM)uM6.431ESR1-GI(Protien) :
PubChem Ratio Potency (uM)uM2.196NFE2L2-GI(Protien) :
PubChem PotencyuM0.002TDP1-GI(Protien) :
PubChem PotencyuM0.002TDP1-GI(Protien) :
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