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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide

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Collection	D4 : CTD
Chemical Name	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide ( From PubChem : H-89 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 446.361 g/mol 2 5 5.4412 False(3/4)
Structure
InChI	InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
InChIKey	ZKZXNDJNWUTGDK-NSCUHMNNSA-N
Links
Gene (66 / 193) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ABCA1 C063509 CTD increases(expression) ABCA1 C063509 CTD decreases(reaction) ABCB1 C063509 CTD increases(expression) ABCB1 C063509 CTD decreases(expression) ABCB1 C063509 CTD decreases(expression) ABCB4 C063509 CTD decreases(reaction) ABCB4 C063509 CTD affects(binding) AHR C063509 CTD decreases(reaction) AHR C063509 CTD increases(reaction) AHR C063509 CTD affects(phosphorylation) AKT1 C063509 CTD decreases(reaction) AKT1 C063509 CTD decreases(reaction) APOA1 C063509 CTD increases(expression) APOA1 C063509 CTD increases(secretion) APOA1 C063509 CTD decreases(reaction) APOE C063509 CTD increases(expression) APOE C063509 CTD increases(secretion) APOE C063509 CTD decreases(reaction) AREG C063509 CTD increases(expression) AREG C063509 CTD decreases(reaction) AREG C063509 CTD increases(expression) AREG C063509 CTD decreases(reaction) ATF1 C063509 CTD increases(phosphorylation) ATF1 C063509 CTD affects(cotreatment) ATF1 C063509 CTD decreases(reaction) ATF1 C063509 CTD increases(phosphorylation) ATF1 C063509 CTD decreases(expression) BIRC5 C063509 CTD decreases(reaction) BIRC5 C063509 CTD decreases(reaction) CCL2 C063509 CTD increases(expression) CCL2 C063509 CTD decreases(reaction) CCND1 C063509 CTD increases(expression) CCND1 C063509 CTD decreases(reaction) CDKN1A C063509 CTD increases(expression) CDKN1A C063509 CTD decreases(reaction) CDKN2B C063509 CTD increases(expression) CDKN2B C063509 CTD decreases(reaction) CETP C063509 CTD increases(expression) CETP C063509 CTD increases(secretion) CETP C063509 CTD affects(localization) CFTR C063509 CTD decreases(reaction) CFTR C063509 CTD increases(activity) CFTR C063509 CTD decreases(reaction) CFTR C063509 CTD increases(phosphorylation) CFTR C063509 CTD decreases(reaction) CFTR C063509 CTD increases(activity) CFTR C063509 CTD decreases(activity) CFTR C063509 CTD decreases(reaction) CGB C063509 CTD increases(abundance) CGB C063509 CTD increases(reaction) CGB C063509 CTD decreases(reaction) COL1A1 C063509 CTD increases(expression) COL1A1 C063509 CTD decreases(reaction) COL3A1 C063509 CTD increases(expression) COL3A1 C063509 CTD decreases(reaction) CREB1 C063509 CTD increases(phosphorylation) CREB1 C063509 CTD decreases(reaction) CREB1 C063509 CTD increases(activity) CREB1 C063509 CTD increases(phosphorylation) CREB1 C063509 CTD affects(localization) CTNNB1 C063509 CTD decreases(reaction) CTNNB1 C063509 CTD affects(binding) CXCL8 C063509 CTD decreases(reaction) CXCL8 C063509 CTD increases(reaction) CXCL8 C063509 CTD decreases(reaction) CXCL8 C063509 CTD increases(secretion) CXCL8 C063509 CTD decreases(reaction) CYP11B1 C063509 CTD increases(expression) CYP11B1 C063509 CTD decreases(reaction) CYP19A1 C063509 CTD increases(expression) CYP19A1 C063509 CTD decreases(reaction) CYP19A1 C063509 CTD increases(expression) CYP19A1 C063509 CTD decreases(reaction) CYP19A1 C063509 CTD increases(expression) CYP19A1 C063509 CTD decreases(reaction) CYP1B1 C063509 CTD increases(expression) CYP1B1 C063509 CTD decreases(reaction) EGFR C063509 CTD increases(expression) EGFR C063509 CTD decreases(reaction) EREG C063509 CTD increases(expression) EREG C063509 CTD decreases(reaction) ESR1 C063509 CTD increases(activity) ESR1 C063509 CTD decreases(reaction) FOS C063509 CTD increases(expression) FOS C063509 CTD affects(cotreatment) FSHB C063509 CTD decreases(reaction) FSHB C063509 CTD increases(chemical synthesis) FSHB C063509 CTD decreases(reaction) FSHB C063509 CTD increases(expression) FSHB C063509 CTD increases(secretion) FSHB C063509 CTD decreases(reaction) GCM1 C063509 CTD increases(activity) GCM1 C063509 CTD decreases(reaction) GSK3B C063509 CTD increases(phosphorylation) GSK3B C063509 CTD decreases(reaction) HMOX1 C063509 CTD increases(expression) HMOX1 C063509 CTD decreases(reaction) ID1 C063509 CTD increases(expression) ID1 C063509 CTD decreases(reaction) IL18 C063509 CTD increases(expression) IL18 C063509 CTD affects(binding) KCNE1 C063509 CTD decreases(reaction) KCNE1 C063509 CTD increases(activity) KCNE1 C063509 CTD decreases(expression) KCNH2 C063509 CTD decreases(reaction) KCNH2 C063509 CTD decreases(expression) KCNJ2 C063509 CTD decreases(reaction) KCNJ2 C063509 CTD affects(binding) KCNQ1 C063509 CTD decreases(reaction) KCNQ1 C063509 CTD increases(activity) KCNQ1 C063509 CTD decreases(reaction) LEP C063509 CTD increases(chemical synthesis) LEP C063509 CTD increases(expression) LEP C063509 CTD decreases(response to substance) LEP C063509 CTD decreases(reaction) LHB C063509 CTD increases(expression) LHB C063509 CTD increases(secretion) LHB C063509 CTD decreases(reaction) MAPK1 C063509 CTD increases(phosphorylation) MAPK1 C063509 CTD decreases(reaction) MAPK1 C063509 CTD increases(phosphorylation) MAPK1 C063509 CTD decreases(reaction) MAPK1 C063509 CTD increases(expression) MAPK1 C063509 CTD decreases(reaction) MAPK3 C063509 CTD increases(phosphorylation) MAPK3 C063509 CTD decreases(reaction) MAPK3 C063509 CTD increases(phosphorylation) MAPK3 C063509 CTD decreases(reaction) MAPK3 C063509 CTD increases(expression) MAPK3 C063509 CTD decreases(reaction) NR4A1 C063509 CTD increases(expression) NR4A1 C063509 CTD affects(cotreatment) NR4A2 C063509 CTD decreases(reaction) NR4A2 C063509 CTD increases(expression) NR4A2 C063509 CTD decreases(reaction) PLA2G4A C063509 CTD increases(expression) PLA2G4A C063509 CTD decreases(reaction) PLD1 C063509 CTD increases(expression) PLD1 C063509 CTD increases(reaction) PLD1 C063509 CTD decreases(expression) PNPLA6 C063509 CTD decreases(activity) PRKCA C063509 CTD affects(cotreatment) PTGER1 C063509 CTD decreases(reaction) PTGER1 C063509 CTD increases(expression) PTGER1 C063509 CTD increases(phosphorylation) PTGER1 C063509 CTD decreases(reaction) PTGS2 C063509 CTD increases(expression) PTGS2 C063509 CTD increases(reaction) PTGS2 C063509 CTD decreases(reaction) PTGS2 C063509 CTD increases(expression) PTGS2 C063509 CTD affects(cotreatment) RELA C063509 CTD decreases(reaction) RELA C063509 CTD increases(phosphorylation) RELA C063509 CTD affects(binding) RELB C063509 CTD decreases(reaction) RELB C063509 CTD increases(reaction) RELB C063509 CTD decreases(activity) RPS6KA5 C063509 CTD decreases(expression) SI C063509 CTD decreases(reaction) SI C063509 CTD decreases(reaction) SLC2A5 C063509 CTD increases(expression) SLC2A5 C063509 CTD increases(stability) SLC2A5 C063509 CTD decreases(reaction) SOD2 C063509 CTD increases(expression) SOD2 C063509 CTD decreases(reaction) STAT3 C063509 CTD increases(activity) STAT3 C063509 CTD increases(phosphorylation) STAT3 C063509 CTD affects(localization) TFAP2A C063509 CTD decreases(reaction) TFAP2A C063509 CTD decreases(reaction) TGFB1 C063509 CTD increases(expression) TGFB1 C063509 CTD decreases(expression) TGFB1 C063509 CTD decreases(reaction) TGFB1 C063509 CTD decreases(reaction) TGFB1 C063509 CTD increases(expression) TGFB1 C063509 CTD decreases(reaction) TNF C063509 CTD increases(expression) TNF C063509 CTD decreases(expression) TNF C063509 CTD decreases(reaction) VASP C063509 CTD increases(phosphorylation) VASP C063509 CTD decreases(expression) XIAP C063509 CTD increases(expression) XIAP C063509 PubChem Potency uM 22.387 ALDH1A1 - GI(Protien) : PubChem Potency uM 15.849 EHMT2 - GI(Protien) : PubChem Potency uM 18.716 TDP1 - GI(Protien) : PubChem Potency uM 20.596 TDP1 - GI(Protien) : PubChem Potency uM 23.562 TDP1 - GI(Protien) : PubChem Potency uM 50.119 EHMT2 - GI(Protien) : PubChem Potency uM 2.818 KCNH2 GI(Protien) : PubChem Potency uM 2.818 KCNH2 GI(Protien) : ChEMBL Potency nM 22387.200 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 15848.900 EHMT2 - Target : CHEMBL6032
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